caa a22 4500 465768857 CHVBK 20180323111923.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF00334502 doi (NATIONALLICENCE)springer-10.1007/BF00334502 Sahenk Z. Department of Neurology, Division of Neuromuscular Disease, The Ohio State University, 465 Means Hall, 1654 Upham Drive, 43210, Columbus, OH, USA aut Distal terminal axonopathy produced by 2,4-dithiobiuret: effects of long-term intoxication in rats [Elektronische Daten] [Z. Sahenk] Summary: It has been well established that 2,4-dithiobiuret (DTB) intoxication in rats produces a rapidly progressive hindlimb paralysis within days. The cause of this has, until recently, been explained on the basis of a physiological abnormality that involves a prejunctional impairment in the neuromuscular transmission alone. The morphological correlate of the electrophysiological abnormalities has now been provided. This study describes the sequential morphological alterations resulting from a chronic long-term DTB intoxication (1 mg/kg per day, IP) in the rat nervous system up to 48 days. The findings indicate that DTB neurotoxicity evolves as a central peripheral distal axonopathy initially affecting the motor nerve terminals which show accumulation of interconnecting branched tubulovesicular profiles. With continued exposure, nerve terminal swelling and degeneration took place. Similar pathological changes in distal axons were observed progressively involving the small intramuscular nerve bundles close to the nerve terminals. Central nervous system axons in the long descending tracts of spinal cord and the cerebellar vermis showed similar changes but to a lesser extent in later stage of intoxication. Springer-Verlag, 1990 Dithiobiuret nationallicence Nerve terminal nationallicence Distal axonopathy nationallicence Tubulovesicular profiles nationallicence Anterogradeto-retrograde conversion process nationallicence Acta Neuropathologica Springer-Verlag 81/2(1990-12-01), 141-147 0001-6322 81:2<141 1990 81 401 https://doi.org/10.1007/BF00334502 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00334502 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Sahenk Z. Department of Neurology, Division of Neuromuscular Disease, The Ohio State University, 465 Means Hall, 1654 Upham Drive, 43210, Columbus, OH, USA aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 81/2(1990-12-01), 141-147 0001-6322 81:2<141 1990 81 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer