caa a22 4500 465768865 CHVBK 20180323111923.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF00334509 doi (NATIONALLICENCE)springer-10.1007/BF00334509 Regional variations in nerve cell responses to trimethyltin intoxication in Mongolian gerbils and rats; further evidence for involvement of the Golgi apparatus [Elektronische Daten] [C. Nolan, A. Brown, J. Cavanagh] Summary: The different responses of neurons with distinctive variations in morphology and function, confirm earlier observations of the lack of uniformity in the reaction of nerve cells to trimethyltin. Thus, hippocampal pyramidal and cortical neurons in both rat and Mongolian gerbil (M. unguiculatus) show abundant lysosomal dense bodies and disorganisation of the protein-synthesising apparatus. Cerebellar Purkinje cells in gerbil, but not in rat, show striking increases in smooth membrane systems, while dense bodies are insignificant in both species; large motor-type neurons in brain stem and spinal cord in both species do not accumulate dense bodies, but their rough endoplasmic reticulum (RER) may undergo intense vacuolation with or without subsequent cell death; and by contrast, spinal ganglion cells of both species may form an excess of dense bodies and, in the gerbil, vacuolation of RER. In contrast with these varied responses to trimethyltin most neurons, large and small, in both species regularly undergo striking vacuolation of the Golgi apparatus in the earliest phase of the intoxication, a constant feature that probably reflects the site of the primary cytotoxic lesion; all other changes we consider are secondary to such damage to the Golgi apparatus, however this may come about. These observations are discussed in relation to earlier reports of the variable effects of trimethyltin and with the metabolic changes reported in trimethyltin intoxication that in general accord with these morphological conclusions. Springer-Verlag, 1990 Rat nationallicence Mongolian gerbil nationallicence Trimethyltin nationallicence Dense bodies nationallicence Golgi appratus nationallicence Nolan C. The Toxicology Unit, M. R. C. Laboratories, SM5 4EF, Carshalton, Surrey, Great Britain aut Brown A. The Toxicology Unit, M. R. C. Laboratories, SM5 4EF, Carshalton, Surrey, Great Britain aut Cavanagh J. The Toxicology Unit, M. R. C. Laboratories, SM5 4EF, Carshalton, Surrey, Great Britain aut Acta Neuropathologica Springer-Verlag 81/2(1990-12-01), 204-212 0001-6322 81:2<204 1990 81 401 https://doi.org/10.1007/BF00334509 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00334509 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nolan C. The Toxicology Unit, M. R. C. Laboratories, SM5 4EF, Carshalton, Surrey, Great Britain aut NATIONALLICENCE 700 1- Brown A. The Toxicology Unit, M. R. C. Laboratories, SM5 4EF, Carshalton, Surrey, Great Britain aut NATIONALLICENCE 700 1- Cavanagh J. The Toxicology Unit, M. R. C. Laboratories, SM5 4EF, Carshalton, Surrey, Great Britain aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 81/2(1990-12-01), 204-212 0001-6322 81:2<204 1990 81 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer