caa a22 4500 465768881 CHVBK 20180323111923.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF00334499 doi (NATIONALLICENCE)springer-10.1007/BF00334499 The complex of microglial cells and amyloid star in three-dimensional reconstruction [Elektronische Daten] [J. Wegiel, H. Wisniewski] Summary: Ultrastructural, three-dimensional reconstruction and morphometric studies of classical plaques from the cortex of a patient with Alzheimer's disease showed five or six microglial cells, which form, together with the amyloid star, the central complex of the classical plaque. Microglial cells associated with the amyloid star show marked polymorphism, but all forms possess an amyloid making pole. The surface of the cell membrane at this pole is extended by apparent connection with membranes of cytoplasmic channels filled with amyloid fibers. The amyloid pole also shows other features of local activation with nuclei translocation, expansion of Golgi apparatus and endoplasmic reticulum, and multiplication of vacuoles and coated vesicles that are in close proximity to channels filled with new polymerized amyloid fibers. On the basis of ultrastructural studies, three forms of microglial cells can be distinguished: macrophage-like, cap-like, and octopus-like cells. The most effective in production of amyloid fibers seem to be cap-like microglial cells, which have the greatest interface with the amyloid star. Octopus-like cells have the least contact with the amyloid star. The size of the surface of the interface with the amyloid star appears to be an indicator of the extent of cell engagement in amyloid fiber formation. Springer-Verlag, 1990 Microglia nationallicence Amyloid star nationallicence Classical plaque nationallicence Three-dimensional reconstruction nationallicence Alzheimer's disease nationallicence Wegiel J. Department of Pathological Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, 10314, Staten Island, NY, USA aut Wisniewski H. Department of Pathological Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, 10314, Staten Island, NY, USA aut Acta Neuropathologica Springer-Verlag 81/2(1990-12-01), 116-124 0001-6322 81:2<116 1990 81 401 https://doi.org/10.1007/BF00334499 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00334499 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wegiel J. Department of Pathological Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, 10314, Staten Island, NY, USA aut NATIONALLICENCE 700 1- Wisniewski H. Department of Pathological Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, 10314, Staten Island, NY, USA aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 81/2(1990-12-01), 116-124 0001-6322 81:2<116 1990 81 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer