caa a22 4500 465768903 CHVBK 20180323111923.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF00334500 doi (NATIONALLICENCE)springer-10.1007/BF00334500 Presence of two different fibril subtypes in the Pick body: an immunoelectron microscopic study [Elektronische Daten] [S. Kato, H. Nakamura] Summary: A study of Pick bodies (PBs) was performed using immunohistochemical, ultrastructural and immunoelectron microscopic techniques. Ultrastructurally, the PBs in the granular neurons of the dentate fascia of Ammon's horn were composed of randomly distributed straight fibrils (14.5±2.1 nm in diameter), intermingled with a few constricted fibrils. The constricted fibrils had a periodicity of 157±11 nm, and were 28.7±3.3 nm wide at their widest point midway between the constrictions and 15.3±3.2 nm wide at the point constriction. A few straight fibrils approximately 15 nm in diameter appeared to morphologically transform into fibrils with constrictions at approximately 160-nm intervals. Immunoelectron microscopy revealed that the straight fibrils, the constricted fibrils, and the transitional form (straight fibrils linked with constricted fibrils) had the same immunoreactivity to anti-tau antiserum. The two different subtypes of Pick fibrils, i.e., the straight fibrils and the constricted fibrils, have interchangeable appearances and a common pathomechanism is suggested to underlie the formation of these two subtypes. Springer-Verlag, 1990 Pick body nationallicence Tau protein nationallicence Straight fibrils nationallicence Constricted fibrils nationallicence Immunoelectron microscopy nationallicence Kato S. Division of Neuropathology, Institute of Neurological Sciences, Tottori University School of Medicine, 86 Nishi-machi, 683, Yonago, Japan aut Nakamura H. Division of Neuropathology, Institute of Neurological Sciences, Tottori University School of Medicine, 86 Nishi-machi, 683, Yonago, Japan aut Acta Neuropathologica Springer-Verlag 81/2(1990-12-01), 125-129 0001-6322 81:2<125 1990 81 401 https://doi.org/10.1007/BF00334500 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00334500 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kato S. Division of Neuropathology, Institute of Neurological Sciences, Tottori University School of Medicine, 86 Nishi-machi, 683, Yonago, Japan aut NATIONALLICENCE 700 1- Nakamura H. Division of Neuropathology, Institute of Neurological Sciences, Tottori University School of Medicine, 86 Nishi-machi, 683, Yonago, Japan aut NATIONALLICENCE 773 0- Acta Neuropathologica Springer-Verlag 81/2(1990-12-01), 125-129 0001-6322 81:2<125 1990 81 401 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer