caa a22 4500 465768997 CHVBK 20180323111923.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF00155545 doi (NATIONALLICENCE)springer-10.1007/BF00155545 Characterization by T1-oligonucleotide fingerprinting of three strains of human hepatitis A virus isolated in Italy [Elektronische Daten] [L. Fiore, E. de Paolis, F. Novello, M. Divizia, A. Panà] Three human hepatitis A virus strains, all of them isolated in Italy but one acquired abroad, were analyzed by T1 - RNAase oligonucleotide mapping and by monoclonal antibody neutralization. The variation among their genomes according to T1 - maps was calculated to be about 9%, thus confirming the poor genomic variation assessed by nucleotide sequencing (1 - 10%). However T1 - maps of these Italian isolates were different from those reported in the literature (Weitz and Siegl, 1985). Neutralization by monoclonal antibody caused a reduction in titres of 2 - 2.5 log10. This genomic stability, if confirmed, is important with a view to a valuable vaccine. Kluwer Academic Publishers, 1990 Human hepatitis A virus nationallicence T1oligonucleotide fingerprinting nationallicence Genomic stability nationallicence Fiore L. Department of Virology, Istituto Superiore di Sanità, Viale Regina Elena, 299 - 00161, Rome, Italy aut de Paolis E. Department of Virology, Istituto Superiore di Sanità, Viale Regina Elena, 299 - 00161, Rome, Italy aut Novello F. Department of Public Health, Tor Vergata University, Via 0. Raimondo, 00173, Rome, Italy aut Divizia M. Department of Public Health, Tor Vergata University, Via 0. Raimondo, 00173, Rome, Italy aut Panà A. Department of Public Health, Tor Vergata University, Via 0. Raimondo, 00173, Rome, Italy aut European Journal of Epidemiology Kluwer Academic Publishers 6/1(1990-03-01), 29-33 0393-2990 6:1<29 1990 6 10654 https://doi.org/10.1007/BF00155545 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00155545 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fiore L. Department of Virology, Istituto Superiore di Sanità, Viale Regina Elena, 299 - 00161, Rome, Italy aut NATIONALLICENCE 700 1- de Paolis E. Department of Virology, Istituto Superiore di Sanità, Viale Regina Elena, 299 - 00161, Rome, Italy aut NATIONALLICENCE 700 1- Novello F. Department of Public Health, Tor Vergata University, Via 0. Raimondo, 00173, Rome, Italy aut NATIONALLICENCE 700 1- Divizia M. Department of Public Health, Tor Vergata University, Via 0. Raimondo, 00173, Rome, Italy aut NATIONALLICENCE 700 1- Panà A. Department of Public Health, Tor Vergata University, Via 0. Raimondo, 00173, Rome, Italy aut NATIONALLICENCE 773 0- European Journal of Epidemiology Kluwer Academic Publishers 6/1(1990-03-01), 29-33 0393-2990 6:1<29 1990 6 10654 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer