caa a22 4500 465769004 CHVBK 20180323111923.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF00155541 doi (NATIONALLICENCE)springer-10.1007/BF00155541 Gonococcal infection within Scotland: Antigenic heterogeneity and antibiotic susceptibility of infecting strains [Elektronische Daten] [H. Young, A. Mopes, D. Robertson, A. McCartney, G. Lindsay, G. Gallacher, I. Tait, O. Brogan, C. Fox, G. Kohiyar, D. Parratt, I. Alexander] Two panels of monoclonal antibody reagents were used to serotype all strains of Neisseria gonorrhoeae isolated from four separate geographical areas serving two million of the five million Scottish population. Serotype 113 isolates accounted for 60% of the 869 strains examined and were more prevalent than 1A isolates in each geographical area. A total of 11 JA serovars and 47 1B serovars were recognised. Only two of the 11 IA serovars (Aedgkih/Arost and Aedih/Arst) were found in every centre but these accounted for over 90% of the IA isolates. Although there was a total of 47 different 113 serovars over 80% of the isolates were accounted for by the ten most commonly encountered serovars. There were, however, marked geographical differences within both major and minor serovars. There was a highly significant difference (P < 0.001) between protein IA and 1B serovars with respect to their susceptibility to penicillin. Within each protein 1 type there were also differences in antibiotic susceptibility. Penicillinase-producing N. gonorrhoeae (PPNG) were found in all centres and accounted for 24 (2.8%) of the 869 isolates. The majority of the PPNG (71%) were serotype IA and with one exception were serovar Aedih/Arst. PPNG strains accounted for 37% (16) of the 43 Aedih/Arst isolates. Epidemiological, diagnostic and therapeutic implications arising from the distinct geographical differences in the pool of circulating gonococci are discussed. Kluwer Academic Publishers, 1990 N. gonorrhoeae nationallicence Serotyping nationallicence Geographical variation nationallicence Antibiotic susceptibility nationallicence PPNG nationallicence Young H. Sexually Transmitted Diseases Diagnostic Laboratory, Department of Bacteriology, Edinburgh University Medical School, EH8 9AG, Edinburgh, Scotland aut Mopes A. Sexually Transmitted Diseases Diagnostic Laboratory, Department of Bacteriology, Edinburgh University Medical School, EH8 9AG, Edinburgh, Scotland aut Robertson D. Genitourinary Medicine Unit, Department of Medicine, Edinburgh University Medical School, EH8 9AG, Edinburgh, Scotland aut McCartney A. Departments of Bacteriology, Glasgow Royal Infirmary, Glasgow Royal Infirmary and Southern General Hospital, Glasgow, Scotland aut Lindsay G. Southern General Hospital, Glasgow Royal Infirmary and Southern General Hospital, Glasgow, Scotland aut Gallacher G. Southern General Hospital, Glasgow Royal Infirmary and Southern General Hospital, Glasgow, Scotland aut Tait I. Department of Genitourinary Medicine, Glasgow Royal Infirmary and Southern General Hospital, Glasgow, Scotland aut Brogan O. Department of Microbiology, Fife Area Laboratory, Victoria Hospital, Kirkcaldy and Dunfermline and West Fife Hospital, Fife, Scotland aut Fox C. Department of Microbiology, Fife Area Laboratory, Victoria Hospital, Kirkcaldy and Dunfermline and West Fife Hospital, Fife, Scotland aut Kohiyar G. Sexually Transmitted Diseases Clinic, Victoria Hospital, Kirkcaldy and Dunfermline and West Fife Hospital, Fife, Scotland aut Parratt D. Department of Medical Microbiology, Ninewells Hospital Dundee, Dundee Royal Infirmary, Dundee, Scotland aut Alexander I. Department of Genitourinary Medicine, Dundee Royal Infirmary, Dundee, Scotland aut European Journal of Epidemiology Kluwer Academic Publishers 6/1(1990-03-01), 1-8 0393-2990 6:1<1 1990 6 10654 https://doi.org/10.1007/BF00155541 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00155541 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Young H. Sexually Transmitted Diseases Diagnostic Laboratory, Department of Bacteriology, Edinburgh University Medical School, EH8 9AG, Edinburgh, Scotland aut NATIONALLICENCE 700 1- Mopes A. Sexually Transmitted Diseases Diagnostic Laboratory, Department of Bacteriology, Edinburgh University Medical School, EH8 9AG, Edinburgh, Scotland aut NATIONALLICENCE 700 1- Robertson D. Genitourinary Medicine Unit, Department of Medicine, Edinburgh University Medical School, EH8 9AG, Edinburgh, Scotland aut NATIONALLICENCE 700 1- McCartney A. Departments of Bacteriology, Glasgow Royal Infirmary, Glasgow Royal Infirmary and Southern General Hospital, Glasgow, Scotland aut NATIONALLICENCE 700 1- Lindsay G. Southern General Hospital, Glasgow Royal Infirmary and Southern General Hospital, Glasgow, Scotland aut NATIONALLICENCE 700 1- Gallacher G. Southern General Hospital, Glasgow Royal Infirmary and Southern General Hospital, Glasgow, Scotland aut NATIONALLICENCE 700 1- Tait I. Department of Genitourinary Medicine, Glasgow Royal Infirmary and Southern General Hospital, Glasgow, Scotland aut NATIONALLICENCE 700 1- Brogan O. Department of Microbiology, Fife Area Laboratory, Victoria Hospital, Kirkcaldy and Dunfermline and West Fife Hospital, Fife, Scotland aut NATIONALLICENCE 700 1- Fox C. Department of Microbiology, Fife Area Laboratory, Victoria Hospital, Kirkcaldy and Dunfermline and West Fife Hospital, Fife, Scotland aut NATIONALLICENCE 700 1- Kohiyar G. Sexually Transmitted Diseases Clinic, Victoria Hospital, Kirkcaldy and Dunfermline and West Fife Hospital, Fife, Scotland aut NATIONALLICENCE 700 1- Parratt D. Department of Medical Microbiology, Ninewells Hospital Dundee, Dundee Royal Infirmary, Dundee, Scotland aut NATIONALLICENCE 700 1- Alexander I. Department of Genitourinary Medicine, Dundee Royal Infirmary, Dundee, Scotland aut NATIONALLICENCE 773 0- European Journal of Epidemiology Kluwer Academic Publishers 6/1(1990-03-01), 1-8 0393-2990 6:1<1 1990 6 10654 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer