caa a22 4500 465769322 CHVBK 20180323111924.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF00150424 doi (NATIONALLICENCE)springer-10.1007/BF00150424 Familial Creutzfeldt-Jakob disease with temporal and spatial separation of affected members [Elektronische Daten] [E. Mitrova, A. Lowenthal, B. Appeal] Familial occurrence of three definitive and two possible cases of Creutzfeldt-Jakob disease (CJD) with temporal and spatial separation in the area of focal CJD accumulation in Slovakia is reported. Incubation period is 51 and 53 years respectively, if spatial and temporal separation of affected siblings is considered, and 51 years when the time interval between the death of the affected mother and the clinical onset in the first affected child is determined. Affected children tend to die at the same time (mean difference 3.3 years) and not at the same age (mean difference 6 years). Due to separation of the affected children, a possible common exposure to CID infection was limited to approximately seven years during their childhood. Potential endo- and exogenous risk factors and a possible mode of CJD transmission in the described family, as well as in the CJD focus, is discussed. Kluwer Academic Publishers, 1990 Familial Creutzfeldt-Jakob disease nationallicence Natural spread nationallicence Genetic susceptibility nationallicence Environmental factors nationallicence Mitrova E. Research Institute of Preventive Medicine, Limbovà 14, 83301, Bratislava, Czecho-Slovakia aut Lowenthal A. Algemen Ziekenhuis Middelheim, Antwerp, Belgium aut Appeal B. Algemen Ziekenhuis Middelheim, Antwerp, Belgium aut European Journal of Epidemiology Kluwer Academic Publishers 6/3(1990-09-01), 233-238 0393-2990 6:3<233 1990 6 10654 https://doi.org/10.1007/BF00150424 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00150424 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mitrova E. Research Institute of Preventive Medicine, Limbovà 14, 83301, Bratislava, Czecho-Slovakia aut NATIONALLICENCE 700 1- Lowenthal A. Algemen Ziekenhuis Middelheim, Antwerp, Belgium aut NATIONALLICENCE 700 1- Appeal B. Algemen Ziekenhuis Middelheim, Antwerp, Belgium aut NATIONALLICENCE 773 0- European Journal of Epidemiology Kluwer Academic Publishers 6/3(1990-09-01), 233-238 0393-2990 6:3<233 1990 6 10654 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer