caa a22 4500 465769403 CHVBK 20180323111925.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF00151710 doi (NATIONALLICENCE)springer-10.1007/BF00151710 Monitoring of the response of elderly individuals to pneumococcal vaccination with the aid of a novel ELISA [Elektronische Daten] [M. Fattal-German, B. Bizzini] An ELISA for assessing pneumococcal anticapsular antibodies in human sera is described. Sensitization was carried out by adding to avidin-coated polystyrene plates biotinylated capsular polyosides. This ELISA was used for the determination of anticapsular antibody levels in pre- and post-immunization sera from 20 elderly individuals. The anticapsular antibody titres differed significantly in sera taken prior to and after vaccination. Eighteen of the 20 sera tested showed mean fold increases of the antibody level greater than 2 (2.1 to 21.0) as a result of vaccination. Since morbidity and mortality rates from S. pneumoniae infections are high in the elderly, immunization should be systematically performed. However, the elderly subject is frequently immunosuppressed, and it is therefore advisable to control the result of the vaccination, using a simple procedure, such as the one described here. Kluwer Academic Publishers, 1990 S. pneumoniae nationallicence Vaccination nationallicence Elderly nationallicence Fattal-German M. Laboratory of Toxin Immunochemistry, Pasteur Institute, 25 et 28, Rue du Docteur Roux, 75724, Paris, Cedex 15 aut Bizzini B. Laboratory of Toxin Immunochemistry, Pasteur Institute, 25 et 28, Rue du Docteur Roux, 75724, Paris, Cedex 15 aut European Journal of Epidemiology Kluwer Academic Publishers 6/4(1990-12-01), 371-375 0393-2990 6:4<371 1990 6 10654 https://doi.org/10.1007/BF00151710 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00151710 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fattal-German M. Laboratory of Toxin Immunochemistry, Pasteur Institute, 25 et 28, Rue du Docteur Roux, 75724, Paris, Cedex 15 aut NATIONALLICENCE 700 1- Bizzini B. Laboratory of Toxin Immunochemistry, Pasteur Institute, 25 et 28, Rue du Docteur Roux, 75724, Paris, Cedex 15 aut NATIONALLICENCE 773 0- European Journal of Epidemiology Kluwer Academic Publishers 6/4(1990-12-01), 371-375 0393-2990 6:4<371 1990 6 10654 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer