caa a22 4500 465769756 CHVBK 20180323111925.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF00145783 doi (NATIONALLICENCE)springer-10.1007/BF00145783 Epidemiological aspects of prenatal exposure to high doses of vitamin a in Spain [Elektronische Daten] [M. Martínez-Frías, J. Salvador] Reports of the human teratogenicity of retinoids have raised concern about the potential human teratogenicity of high doses of vitamin A. Nevertheless, there are few human case reports of excess intake of vitamin A during pregnancy and defective outcomes. No epidemiological studies have been carried out on this subject. Here we present the results of an epidemiological study of prenatal exposure to high doses of vitamin A in Spain, using data from the Spanish hospital-based, case-control registry. Although it is difficult to reach conclusions with such a very low exposure level (1.3 per 1,000 livebirths), our results suggest that a teratogenic effect might exist for exposures to high doses of vitamin A (OR = 0.5, p = 0.15 for less than 40,000 FU and OR = 2.7, p = 0.06 for 40,000 1U or more). As we might expect, this effect also seems to be related to the organogenetic status (OR = 5.4, p = 0.1 for 1st −2nd month, OR = 1.8, p = 0.4 for 3rd onwards) at the time of exposure. Gustav Fischer, 1990 Retinoids nationallicence Vitamin A exposure nationallicence Teratogenicity nationallicence Martínez-Frías M. ECEMC. Facultad de Medicina, Universidad Complutense, 28040, Madrid, Spain aut Salvador J. ECEMC. Facultad de Medicina, Universidad Complutense, 28040, Madrid, Spain aut European Journal of Epidemiology Kluwer Academic Publishers 6/2(1990-06-01), 118-123 0393-2990 6:2<118 1990 6 10654 https://doi.org/10.1007/BF00145783 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00145783 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Martínez-Frías M. ECEMC. Facultad de Medicina, Universidad Complutense, 28040, Madrid, Spain aut NATIONALLICENCE 700 1- Salvador J. ECEMC. Facultad de Medicina, Universidad Complutense, 28040, Madrid, Spain aut NATIONALLICENCE 773 0- European Journal of Epidemiology Kluwer Academic Publishers 6/2(1990-06-01), 118-123 0393-2990 6:2<118 1990 6 10654 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer