caa a22 4500 465771785 CHVBK 20180323111931.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF00174338 doi (NATIONALLICENCE)springer-10.1007/BF00174338 Indomethacin for prevention of stricture formation due to alkali-induced corrosive esophageal burns in the rat [Elektronische Daten] Biochemical analysis [Mehmet Pul, Nuran Yilmaz, Orhan Değer, Naci Gürses] The aim of this study was to investigate the therapeutic effect of indomethacin on corrosive esophageal strictures. Esophageal burns were produced in 40 of 50 Sprague-Dawley rats by 10.7% NaOH and were then grouped as pure esophageal burns, esophageal burns treated with indomethacin, and controls. All of the animals were killed on the 28th day of the experiment and hydroxyproline levels in esophageal tissue were determined for each rat. Hydroxyproline levels were significantly lower in the indomethacin-treated group than in the other two groups. Based on our results, we suggest that indomethacin inhibited collagen synthesis and thus alkali-induced esophageal stricture formation. Springer-Verlag, 1990 Indomethacin nationallicence Esophageal stricture nationallicence Caustic ingestion nationallicence Pul Mehmet Departments of Pediatric Surgery, Medical Faculty, Trabzon and Samsun, Turkey aut Yilmaz Nuran Departments of Pediatrics, Medical Faculty, Trabzon and Samsun, Turkey aut Değer Orhan Deaprtments of Biochemistry of Karadeniz Technical and Ondokuzmayis Unversity, Medical Faculty, Trabzon and Samsun, Turkey aut Gürses Naci Departments of Pediatric Surgery, Medical Faculty, Trabzon and Samsun, Turkey aut Pediatric Surgery International Springer-Verlag 5/6(1990-11-01), 416-417 0179-0358 5:6<416 1990 5 383 https://doi.org/10.1007/BF00174338 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00174338 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pul Mehmet Departments of Pediatric Surgery, Medical Faculty, Trabzon and Samsun, Turkey aut NATIONALLICENCE 700 1- Yilmaz Nuran Departments of Pediatrics, Medical Faculty, Trabzon and Samsun, Turkey aut NATIONALLICENCE 700 1- Değer Orhan Deaprtments of Biochemistry of Karadeniz Technical and Ondokuzmayis Unversity, Medical Faculty, Trabzon and Samsun, Turkey aut NATIONALLICENCE 700 1- Gürses Naci Departments of Pediatric Surgery, Medical Faculty, Trabzon and Samsun, Turkey aut NATIONALLICENCE 773 0- Pediatric Surgery International Springer-Verlag 5/6(1990-11-01), 416-417 0179-0358 5:6<416 1990 5 383 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer