caa a22 4500 465772714 CHVBK 20180323111933.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF00178225 doi (NATIONALLICENCE)springer-10.1007/BF00178225 Endorphin and cortisol responses to surgical stress in newborns and infants [Elektronische Daten] Preliminary report [Jiin-Haur Chuang, Jer-Nan Lin, Ju-Hao Lee, Bruno Jawan, Si-Tun Fung, Pei-Wen Wang] The beta-endorphin (BE) response to surgical stress in newborns and infants and its relation to pituitary-adrenal dynamics during stress is still unknown. Nine newborns 5 h to 5 days of age, and 5 infants 5 to 10 months old undergoing surgery were studied. All patients were anesthetized with N2O-O2 and halothane. Blood samples for BE and cortisol determinations were taken preoperatively and 30 min, 12 h, and 24 h after operation for radioimmunoassay. Both BE and cortisol levels in newborns were not significantly different from those in infants preoperatively (196±85.2 pg/ml vs. 138±47.8 pg/ml for BE and 23.7±17.5 μg/dl vs. 10.1±5.6 μg/dl for cortisol, P >0.05). At 30 min after operation, no significant increase in BE (220±106 pg/ml) and cortisol (36.1±21.2 μg/dl) was found in newborns, while significant increases (BE 493±281 pg/ml, cortisol 43.9±24.2 μg/dl) were found in infants compared to preoperative levels (both P <0.05). A significant difference between groups was seen in BE but not cortisol levels 30 min after operation. Both BE and cortisol declined to preoperative values within 24 h after surgery. Our study showed significant BE and cortisol responses to surgical stress in infants, but not in newborns. Factors such as age-related differential responses to the same anesthetic technique, duration of operation, and developmental differences in stress response are considered responsible for the differences. Springer-Verlag, 1990 Endorphin nationallicence Cortisol nationallicence Stress nationallicence Chuang Jiin-Haur Division of Pediatric Surgery, Department of Surgery, Chang Gung Memorial Hospital, Kaoshiung, Chang Gung Medical College, Taipei, Taiwan, Republic of China aut Lin Jer-Nan Division of Pediatric Surgery, Department of Surgery, Chang Gung Memorial Hospital, Kaoshiung, Chang Gung Medical College, Taipei, Taiwan, Republic of China aut Lee Ju-Hao Department of Anesthesiology, Chang Gung Memorial Hospital, Kaoshiung, Chang Gung Medical College, Taipei, Taiwan, Republic of China aut Jawan Bruno Department of Anesthesiology, Chang Gung Memorial Hospital, Kaoshiung, Chang Gung Medical College, Taipei, Taiwan, Republic of China aut Fung Si-Tun Department of Anesthesiology, Chang Gung Memorial Hospital, Kaoshiung, Chang Gung Medical College, Taipei, Taiwan, Republic of China aut Wang Pei-Wen Department of Nuclear Medicine, Chang Gung Memorial Hospital Kaoshiung, Chang Gung Medical College, Taipei, Taiwan, Republic of China aut Pediatric Surgery International Springer-Verlag 5/2(1990-02-01), 100-102 0179-0358 5:2<100 1990 5 383 https://doi.org/10.1007/BF00178225 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00178225 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chuang Jiin-Haur Division of Pediatric Surgery, Department of Surgery, Chang Gung Memorial Hospital, Kaoshiung, Chang Gung Medical College, Taipei, Taiwan, Republic of China aut NATIONALLICENCE 700 1- Lin Jer-Nan Division of Pediatric Surgery, Department of Surgery, Chang Gung Memorial Hospital, Kaoshiung, Chang Gung Medical College, Taipei, Taiwan, Republic of China aut NATIONALLICENCE 700 1- Lee Ju-Hao Department of Anesthesiology, Chang Gung Memorial Hospital, Kaoshiung, Chang Gung Medical College, Taipei, Taiwan, Republic of China aut NATIONALLICENCE 700 1- Jawan Bruno Department of Anesthesiology, Chang Gung Memorial Hospital, Kaoshiung, Chang Gung Medical College, Taipei, Taiwan, Republic of China aut NATIONALLICENCE 700 1- Fung Si-Tun Department of Anesthesiology, Chang Gung Memorial Hospital, Kaoshiung, Chang Gung Medical College, Taipei, Taiwan, Republic of China aut NATIONALLICENCE 700 1- Wang Pei-Wen Department of Nuclear Medicine, Chang Gung Memorial Hospital Kaoshiung, Chang Gung Medical College, Taipei, Taiwan, Republic of China aut NATIONALLICENCE 773 0- Pediatric Surgery International Springer-Verlag 5/2(1990-02-01), 100-102 0179-0358 5:2<100 1990 5 383 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer