caa a22 4500 465772781 CHVBK 20180323111933.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF00178227 doi (NATIONALLICENCE)springer-10.1007/BF00178227 Segmental response of the lower esophageal sphincter to increased intragastric pressure [Elektronische Daten] An experimental study in cats [Carlos Bardaji, José Ochoa, José Pavao] An important controversy exists concerning the adaptive capacity of the lower esophageal sphincter (LES) in response to increases in intragastric pressure. This capacity would characterize the LES as a dynamic element in preventing gastroesophageal reflux (GER). This physiological property was studied in 15 male cats using an experimental model in which the gastroesophageal antireflux barrier was generated eyclusively by the intrinsic tone of the LES. Under these conditions, the intragastric pressure (GP) and sphincter pressure (LESP) were measured by electromanometric procedures. When the gastric lumen was perfused with known volumes (25, 50, 75, 100, 125, 150 ml) of saline solution, increases in GP and LESP were observed. Both pressures increased slowly as the gastric volume rose, and when both values were equal, GER appeared. Studying the physiological properties of the LES by direct methods in this model, we conclude that (a) there is segmental pressure response of the LES when faced with direct opening stimulation such as an increase in GP; and (b) the increase in LES resting tone has a linear relation with the increase in GP. Springer-Verlag, 1990 Lower esophageal sphincter nationallicence Gastroesophageal junction nationallicence Esophageal manometry nationallicence Experimental study nationallicence Bardaji Carlos Department of Pediatric Surgery, Children's Hospital, The Autonomous University of Barcelona, Spain aut Ochoa José Department of Pediatric Surgery, Children's Hospital, The Autonomous University of Barcelona, Spain aut Pavao José Department of Pediatric Surgery, Children's Hospital, The Autonomous University of Barcelona, Spain aut Pediatric Surgery International Springer-Verlag 5/2(1990-02-01), 106-109 0179-0358 5:2<106 1990 5 383 https://doi.org/10.1007/BF00178227 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00178227 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bardaji Carlos Department of Pediatric Surgery, Children's Hospital, The Autonomous University of Barcelona, Spain aut NATIONALLICENCE 700 1- Ochoa José Department of Pediatric Surgery, Children's Hospital, The Autonomous University of Barcelona, Spain aut NATIONALLICENCE 700 1- Pavao José Department of Pediatric Surgery, Children's Hospital, The Autonomous University of Barcelona, Spain aut NATIONALLICENCE 773 0- Pediatric Surgery International Springer-Verlag 5/2(1990-02-01), 106-109 0179-0358 5:2<106 1990 5 383 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer