caa a22 4500 465772897 CHVBK 20180323111933.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00505644 doi (NATIONALLICENCE)springer-10.1007/BF00505644 Ultraviolet radiation suppresses mouse-ear edema induced by topical application of arachidonic acid [Elektronische Daten] [K. Danno, K. Toda, K. Ikai, T. Horio, S. Imamura] Summary: The effect of ultraviolet (UV) radiation on arachidonic acid (AA) cascade was examined using an in vivo model. Mouse ear lobes were painted with 1 mg AA, and the maximum response of ear swelling was measured 1 h after challenge. Arachidonic-acid-induced ear swelling was significantly suppressed by preexposure to topical psoralen plus noninflammatory doses of long-wave UV radiation (PUVA) or middle-wave UV (UVB) radiation. Ultraviolet radiation may interfere with AA pathways to suppress ear swelling since AA-induced ear swelling is considered to be mediated by metabolites derived from exogenous AA. The results may relate to the therapeutic mechanisms of UV radiation in psoriasis in which the eicosanoid cascade is involved. Springer-Verlag, 1990 Arachidonic acid nationallicence Mouse ear edema nationallicence PUVA nationallicence Ultraviolet radiation nationallicence UVB nationallicence Danno K. Department of Dermatology, Tenri Hospital, 200 Mishima, 632, Tenri-City, Japan aut Toda K. Department of Dermatology, Kitano Hospital, Osaka-City, Japan aut Ikai K. Department of Dermatology, Faculty of Medicine Kyoto University, Kyoto-City, Japan aut Horio T. Department of Dermatology, Faculty of Medicine Kyoto University, Kyoto-City, Japan aut Imamura S. Department of Dermatology, Faculty of Medicine Kyoto University, Kyoto-City, Japan aut Archives of Dermatological Research Springer-Verlag 282/1(1990-01-01), 42-46 0340-3696 282:1<42 1990 282 403 https://doi.org/10.1007/BF00505644 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00505644 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Danno K. Department of Dermatology, Tenri Hospital, 200 Mishima, 632, Tenri-City, Japan aut NATIONALLICENCE 700 1- Toda K. Department of Dermatology, Kitano Hospital, Osaka-City, Japan aut NATIONALLICENCE 700 1- Ikai K. Department of Dermatology, Faculty of Medicine Kyoto University, Kyoto-City, Japan aut NATIONALLICENCE 700 1- Horio T. Department of Dermatology, Faculty of Medicine Kyoto University, Kyoto-City, Japan aut NATIONALLICENCE 700 1- Imamura S. Department of Dermatology, Faculty of Medicine Kyoto University, Kyoto-City, Japan aut NATIONALLICENCE 773 0- Archives of Dermatological Research Springer-Verlag 282/1(1990-01-01), 42-46 0340-3696 282:1<42 1990 282 403 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer