caa a22 4500 465772919 CHVBK 20180323111934.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00505642 doi (NATIONALLICENCE)springer-10.1007/BF00505642 Intranuclear androgen and cytosolic receptor concentrations in the axillary skin of osmidrosis [Elektronische Daten] [S. Kurata, S. Itami, S. Komada, S. Takayasu] Summary: 5α-Dihydrotestosterone (DHT) and testosterone were measured by radioimmunoassay in the crude nuclear and cytoplasmic fractions of the axillary skin of both male and female patients with osmidrosis and the levels compared with those of nongenital skin. The intranuclear levels of DHT were 1.44±0.22 and 1.77±0.38 pg/Μg DNA in men and women, respectively. Those of testosterone were about 10% of DHT levels. In the skin of nontarget regions nuclear DHT was much scarcer or undetectable. Cytosolic androgen receptors in isolated apocrine glands were also measured using 3H-R1881 as a ligand. Typical androgen receptors were present in all of eight patients (KD=1.32 ±0.24×10−9M, Bmax=10.3±0.51 fmol/mg protein). Neither the intranuclear androgen concentrations nor the cytosolic androgen receptor levels were significantly different between the two sexes. These data indicate clearly that the apocrine gland of patients with osmidrosis is a typical androgen target organ, irrespective of sex, and suggest that nuclear DHT in the axillary skin of women is derived from not only testosterone but also other precursors, especially in consideration of the very low serum concentrations of testosterone in females. Springer-Verlag, 1990 Apocrine gland nationallicence Intranuclear androgen nationallicence Androgen receptor nationallicence Osmidrosis nationallicence Kurata S. Department of Dermatology, Medical College of Oita, 1-1506, Idaigaoka, Hazamacho, Oita-gun, 879-56, Oita, Japan aut Itami S. Department of Dermatology, Medical College of Oita, 1-1506, Idaigaoka, Hazamacho, Oita-gun, 879-56, Oita, Japan aut Komada S. Department of Dermatology, Medical College of Oita, 1-1506, Idaigaoka, Hazamacho, Oita-gun, 879-56, Oita, Japan aut Takayasu S. Department of Dermatology, Medical College of Oita, 1-1506, Idaigaoka, Hazamacho, Oita-gun, 879-56, Oita, Japan aut Archives of Dermatological Research Springer-Verlag 282/1(1990-01-01), 33-37 0340-3696 282:1<33 1990 282 403 https://doi.org/10.1007/BF00505642 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00505642 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kurata S. Department of Dermatology, Medical College of Oita, 1-1506, Idaigaoka, Hazamacho, Oita-gun, 879-56, Oita, Japan aut NATIONALLICENCE 700 1- Itami S. Department of Dermatology, Medical College of Oita, 1-1506, Idaigaoka, Hazamacho, Oita-gun, 879-56, Oita, Japan aut NATIONALLICENCE 700 1- Komada S. Department of Dermatology, Medical College of Oita, 1-1506, Idaigaoka, Hazamacho, Oita-gun, 879-56, Oita, Japan aut NATIONALLICENCE 700 1- Takayasu S. Department of Dermatology, Medical College of Oita, 1-1506, Idaigaoka, Hazamacho, Oita-gun, 879-56, Oita, Japan aut NATIONALLICENCE 773 0- Archives of Dermatological Research Springer-Verlag 282/1(1990-01-01), 33-37 0340-3696 282:1<33 1990 282 403 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer