caa a22 4500 465772951 CHVBK 20180323111934.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00505638 doi (NATIONALLICENCE)springer-10.1007/BF00505638 No evidence for the mutation of ras gene in psoriatic epidermis [Elektronische Daten] [H. Takahashi, H. Iizuka, M. Katagiri] Summary: The ras oncogene product, ras p21, is structurally homologous to guanine nucleotide-binding proteins, which play an important role in transmembrane signaling systems. Recently, enhanced expression of ras p21 has been reported in the psoriatic hyperproliferative epidermis, in which various alterations in the transmembrane signaling systems are well established. Since ras-proto-oncogenes are known to be activated by a single point mutation that is restricted to the amino acid residues either at position 12, 61 or in their vicinity, we investigated whether the increased expression of ras p21 in psoriatic epidermis is accompanied by mutation of the ras gene at these sites. The results obtained using samples from five cases of psoriasis revealed no evidence for such mutation. Although the psoriatic epidermis may exhibit enhanced expression of ras p21, this is apparently not accompanied by ras mutation. Springer-Verlag, 1990 Psoriasis nationallicence ras Gene nationallicence Epidermis nationallicence Takahashi H. Department of Dermatology, Asahikawa Medical College, Asahikawa, Japan aut Iizuka H. Department of Dermatology, Asahikawa Medical College, Asahikawa, Japan aut Katagiri M. Department of Pathology, Asahikawa Medical College, Asahikawa, Japan aut Archives of Dermatological Research Springer-Verlag 282/1(1990-01-01), 8-11 0340-3696 282:1<8 1990 282 403 https://doi.org/10.1007/BF00505638 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00505638 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takahashi H. Department of Dermatology, Asahikawa Medical College, Asahikawa, Japan aut NATIONALLICENCE 700 1- Iizuka H. Department of Dermatology, Asahikawa Medical College, Asahikawa, Japan aut NATIONALLICENCE 700 1- Katagiri M. Department of Pathology, Asahikawa Medical College, Asahikawa, Japan aut NATIONALLICENCE 773 0- Archives of Dermatological Research Springer-Verlag 282/1(1990-01-01), 8-11 0340-3696 282:1<8 1990 282 403 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer