caa a22 4500 46577296X CHVBK 20180323111934.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00505640 doi (NATIONALLICENCE)springer-10.1007/BF00505640 Stereographic analysis of syringomas [Elektronische Daten] [M. Ito, H. Yokoyama, K. Ikeda, Y. Sato] Summary: To investigate biological characteristics of syringomas, three-dimensional (3-D) architectures of epithelial tumor nests and luminal structures of syringomas, hair follicles, and epidermal basement membrane in skin lesions were reconstructed using a computer stereographic analysis. Each lesion was composed of many spherical- to ovoid-shaped tumor nests, which interconnected with each other by narrow tumor strands, showing features of ginger roots or budding fungi. Small discrete tumor nests were often present in the peripheral areas of the lesions. Tumor nests developed around hair follicles and beneath epidermis, but they were never connected with hair follicles or epidermal basement membrane, although occasionally such structures were slightly bent by a pressure from the developing tumor nests. There was no relationship between tumor nests and normal sweat glands. Many tumor nests formed luminal structures; however, some small tumor nests did not. Most of the luminal structures were disconnectedly present. These findings suggest that in each lesion syringoma may occur in a single focus in the upper dermis without a relationship to the surrounding normal epithelial tissues, develop and partly swell forming lumina, and then the peripheral parts of the tumor may become discrete. The ratio of [lumen volume/ tumor nest volume] measured by computer stereometry was 0.275±0.037 (n=5); this indicates a constant ability to form luminal structures by syringoma cells. Springer-Verlag, 1990 Syringoma nationallicence Three-dimensional structures nationallicence Stereography nationallicence Stereometry nationallicence Ito M. Department of Dermatology, Niigata University School of Medicine, 951, Niigata, Japan aut Yokoyama H. Department of Dermatology, Niigata University School of Medicine, 951, Niigata, Japan aut Ikeda K. Department of Dermatology, Niigata University School of Medicine, 951, Niigata, Japan aut Sato Y. Department of Dermatology, Niigata University School of Medicine, 951, Niigata, Japan aut Archives of Dermatological Research Springer-Verlag 282/1(1990-01-01), 17-21 0340-3696 282:1<17 1990 282 403 https://doi.org/10.1007/BF00505640 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00505640 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ito M. Department of Dermatology, Niigata University School of Medicine, 951, Niigata, Japan aut NATIONALLICENCE 700 1- Yokoyama H. Department of Dermatology, Niigata University School of Medicine, 951, Niigata, Japan aut NATIONALLICENCE 700 1- Ikeda K. Department of Dermatology, Niigata University School of Medicine, 951, Niigata, Japan aut NATIONALLICENCE 700 1- Sato Y. Department of Dermatology, Niigata University School of Medicine, 951, Niigata, Japan aut NATIONALLICENCE 773 0- Archives of Dermatological Research Springer-Verlag 282/1(1990-01-01), 17-21 0340-3696 282:1<17 1990 282 403 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer