caa a22 4500 465773095 CHVBK 20180323111934.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF00372084 doi (NATIONALLICENCE)springer-10.1007/BF00372084 The ultrastructure of dysplastic naevi: comparison with superficial spreading melanoma and common naevocellular naevi [Elektronische Daten] [K. Langer, K. Rappersberger, A. Steiner, K. Konrad, K. Wolff] Summary: Eleven dysplastic melanocytic naevi with various degrees of dysplasia, as judged by light microscopy, were studied by transmission electron microscopy, and their intra-epidermal melanocytes compared with those of five superficial spreading melanomas and seven common benign naevocellular naevi. Intra-epidermal melanocytes in dysplastic naevi exhibited signs of cellular atypia, which were most pronounced in the dysplastic naevi with histological high-grade dysplasia. A correlation between the degree of dysplasia at the light microscopic level and the degree of cytological atypia at the ultrastructural level was noted, and melanocytes in dysplastic naevi with a high degree of dysplasia had ultrastructural features similar to the melanocytes in superficial spreading melanomas. Our observations support the concept that dysplastic naevi fill the biological gap between benign naevocellular naevi and malignant melanomas and suggest that at least some of the dysplastic naevi must be regarded as potential precursor lesions of malignant melanoma, particularly those exhibiting a high degree of histological dysplasia. Springer-Verlag, 1990 Dysplastic naevi nationallicence Superficial spreading melanoma nationallicence Naevocellular naevi nationallicence Ultrastructure nationallicence Melanosomes nationallicence Langer K. Department of Dermatology I, University of Vienna Medical School, Alser Strasse 4, A-1090, Vienna, Austria aut Rappersberger K. Department of Dermatology I, University of Vienna Medical School, Alser Strasse 4, A-1090, Vienna, Austria aut Steiner A. Department of Dermatology I, University of Vienna Medical School, Alser Strasse 4, A-1090, Vienna, Austria aut Konrad K. Department of Dermatology I, University of Vienna Medical School, Alser Strasse 4, A-1090, Vienna, Austria aut Wolff K. Department of Dermatology I, University of Vienna Medical School, Alser Strasse 4, A-1090, Vienna, Austria aut Archives of Dermatological Research Springer-Verlag 282/6(1990-09-01), 353-362 0340-3696 282:6<353 1990 282 403 https://doi.org/10.1007/BF00372084 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00372084 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Langer K. Department of Dermatology I, University of Vienna Medical School, Alser Strasse 4, A-1090, Vienna, Austria aut NATIONALLICENCE 700 1- Rappersberger K. Department of Dermatology I, University of Vienna Medical School, Alser Strasse 4, A-1090, Vienna, Austria aut NATIONALLICENCE 700 1- Steiner A. Department of Dermatology I, University of Vienna Medical School, Alser Strasse 4, A-1090, Vienna, Austria aut NATIONALLICENCE 700 1- Konrad K. Department of Dermatology I, University of Vienna Medical School, Alser Strasse 4, A-1090, Vienna, Austria aut NATIONALLICENCE 700 1- Wolff K. Department of Dermatology I, University of Vienna Medical School, Alser Strasse 4, A-1090, Vienna, Austria aut NATIONALLICENCE 773 0- Archives of Dermatological Research Springer-Verlag 282/6(1990-09-01), 353-362 0340-3696 282:6<353 1990 282 403 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer