caa a22 4500 46577315X CHVBK 20180323111934.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF00372087 doi (NATIONALLICENCE)springer-10.1007/BF00372087 Detection of migration inhibitory factor (MIF) by a monoclonal antibody in the microvasculature of inflamed skin [Elektronische Daten] [R. Schlegel Gómez, T. Diepgen, C. Neumann, C. Sorg] Summary: Macrophage migration inhibitory factor (MIF) is known as a mediator of cellular immunity with specific effects on the differentiation of mononuclear phagocytes. There is little information on the production of MIF in vivo and its role in the pathophysiology of inflammation. We studied the distribution of MIF in various tissues with a monoclonal antibody against human MIF (1C5/B) using the indirect immunoperoxidase method. Here, we investigate the expression of MIF on endothelial cells of dermal vessels. Our results show that dermal vessels may constitutively express MIF and can be strongly activated to express MIF in acute inflammations such as eczema and psoriasis in contrast to the chronically infiltrated skin from patients with pseudolymphomas and sarcoidosis. In these cases a possibly MIF defective state of vessels and a restriction of positive vessels to distinct anatomical sites of the inflamed skin was detected. The significance of the described association of MIF with vascular endothelium is still a matter of speculation. MIF expression on endothelium may provide an important differentiogenic signal for mononculear phagocytes on their way to the tissue site. Springer-Verlag, 1990 Migration inhibitory factor (MIF) nationallicence Endothelial cells nationallicence Mononuclear phagocytes nationallicence Inflammations nationallicence Schlegel Gómez R. Department of Dermatology, University of Erlangen-Nürnberg, Hartmannstrasse 14, D-8520, Erlangen, Germany aut Diepgen T. Department of Dermatology, University of Erlangen-Nürnberg, Hartmannstrasse 14, D-8520, Erlangen, Germany aut Neumann C. Department of Dermatology, University of Hannover, Germany aut Sorg C. Institute of Experimental Dermatology, University of Münster, Germany aut Archives of Dermatological Research Springer-Verlag 282/6(1990-09-01), 374-378 0340-3696 282:6<374 1990 282 403 https://doi.org/10.1007/BF00372087 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00372087 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schlegel Gómez R. Department of Dermatology, University of Erlangen-Nürnberg, Hartmannstrasse 14, D-8520, Erlangen, Germany aut NATIONALLICENCE 700 1- Diepgen T. Department of Dermatology, University of Erlangen-Nürnberg, Hartmannstrasse 14, D-8520, Erlangen, Germany aut NATIONALLICENCE 700 1- Neumann C. Department of Dermatology, University of Hannover, Germany aut NATIONALLICENCE 700 1- Sorg C. Institute of Experimental Dermatology, University of Münster, Germany aut NATIONALLICENCE 773 0- Archives of Dermatological Research Springer-Verlag 282/6(1990-09-01), 374-378 0340-3696 282:6<374 1990 282 403 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer