caa a22 4500 465773192 CHVBK 20180323111934.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF00402616 doi (NATIONALLICENCE)springer-10.1007/BF00402616 Epidermal cell surface-associated IgG in patients with primary Sjögren's syndrome: in vitro evidence for immune complex binding [Elektronische Daten] [P. Oxholm, A. Oxholm, B. Thomsen, L. Braathen] Summary: In vivo deposits of IgG have previously been demonstrated in the epidermal intercellular area of clinically unaffected skin from 68% of patients with primary Sjögren's syndrome (primary SS). This study compared circulating IgG from patients with primary SS with that from secondary SS in their ability to bind normal human epidermal cells in vitro. We observed a granular pattern of IgG binding to the normal epidermal cell surfaces with 9 of 18 sera from patients with primary SS (50%), 3 of 19 sera from patients with SS secondary to rheumatoid arthritis (16%) (p=0.025), and none of 24 normal control sera (p<0.001). In a subsequent analysis of polyethylene glycol separated sera from two normal controls and two primary SS patients, the epidermal IgG binding capacity was found only in the precipitates of the patients. These findings support our previous hypothesis that the in vivo intraepithelial IgG deposits in primary SS patients are due, at least in part, to cell surface-bound immune complexes. Springer-Verlag, 1990 Primary Sjögren's syndrome nationallicence Epidermal IgG deposits nationallicence Anti-nuclear antibodies nationallicence Immune complexes nationallicence Oxholm P. Department of Rheumatology TTA, Rigshospitalet, Tagensvej 20, DK-2200, Copenhagen N, Denmark aut Oxholm A. Departments of Stomatology and Dermatology, University of California, San Francisco, USA aut Thomsen B. Department of Rheumatology TTA, Rigshospitalet, Tagensvej 20, DK-2200, Copenhagen N, Denmark aut Braathen L. Department of Dermatology, Rikshospitalet, Oslo, Norway aut Archives of Dermatological Research Springer-Verlag 282/7(1990-10-01), 423-427 0340-3696 282:7<423 1990 282 403 https://doi.org/10.1007/BF00402616 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00402616 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Oxholm P. Department of Rheumatology TTA, Rigshospitalet, Tagensvej 20, DK-2200, Copenhagen N, Denmark aut NATIONALLICENCE 700 1- Oxholm A. Departments of Stomatology and Dermatology, University of California, San Francisco, USA aut NATIONALLICENCE 700 1- Thomsen B. Department of Rheumatology TTA, Rigshospitalet, Tagensvej 20, DK-2200, Copenhagen N, Denmark aut NATIONALLICENCE 700 1- Braathen L. Department of Dermatology, Rikshospitalet, Oslo, Norway aut NATIONALLICENCE 773 0- Archives of Dermatological Research Springer-Verlag 282/7(1990-10-01), 423-427 0340-3696 282:7<423 1990 282 403 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer