caa a22 4500 465773222 CHVBK 20180323111934.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF00402623 doi (NATIONALLICENCE)springer-10.1007/BF00402623 Effect of tumour necrosis factor in the mouse-tail model of psoriasis [Elektronische Daten] [K. Nagano, K. Hori, T. Nagane, T. Sugawara, J. Oh-ishi, H. Hayashi, N. Watanabe, Y. Niitsu] Summary: The effects of local and systemic administration of tumour necrosis factor (TNF) on the mouse-tail model of psoriasis were examined histologically at 4 days after administration. Subcutaneous injection of TNF at 1×101 to 1×104 units/mouse resulted in dose-dependent formation of a granular layer in the tail scales, which was quantified as the percentage of tail scales having granular layer formations extending over half or more of their surface and was larger than that occurring in untreated mice and in mice receiving injections of vehicle solution alone. Daily intraperitoneal injection of TNF at 1×103 or 1×104 units/mouse for 28 days resulted in similar granular layer formation and in a significantly reduced mitotic index of the tail keratinocytes, indicating an antiproliferative effect of TNF. The lowered mitotic index and the induction of granular layers, apparently attributable to a modulation of keratinocyte proliferation and differentiation by TNF, suggest that TNF may be effective as a drug for treatment of psoriasis. Springer-Verlag, 1990 Tumour necrosis factor nationallicence Mouse tail epidermis nationallicence Granular layer nationallicence Keratinocytes nationallicence Psoriasis nationallicence Nagano K. Pharmaceuticals Laboratory, Asahi Chemical Industry Company, Ltd, Fuji-City, Shizuoka, Japan aut Hori K. Pharmaceuticals Laboratory, Asahi Chemical Industry Company, Ltd, Fuji-City, Shizuoka, Japan aut Nagane T. Pharmacological Research Team, Life Science Research Laboratories, Asahi Chemical Industry Company, Ltd, Fuji-City, Shizuoka, Japan aut Sugawara T. Pharmacological Research Team, Life Science Research Laboratories, Asahi Chemical Industry Company, Ltd, Fuji-City, Shizuoka, Japan aut Oh-ishi J. Pharmacological Research Team, Life Science Research Laboratories, Asahi Chemical Industry Company, Ltd, Fuji-City, Shizuoka, Japan aut Hayashi H. Pharmaceuticals Laboratory, Asahi Chemical Industry Company, Ltd, Fuji-City, Shizuoka, Japan aut Watanabe N. Department of Internal Medicine (Section 4), Sapporo Medical College, Chuo-ku, Sapporo, Japan aut Niitsu Y. Department of Internal Medicine (Section 4), Sapporo Medical College, Chuo-ku, Sapporo, Japan aut Archives of Dermatological Research Springer-Verlag 282/7(1990-10-01), 459-462 0340-3696 282:7<459 1990 282 403 https://doi.org/10.1007/BF00402623 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00402623 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nagano K. Pharmaceuticals Laboratory, Asahi Chemical Industry Company, Ltd, Fuji-City, Shizuoka, Japan aut NATIONALLICENCE 700 1- Hori K. Pharmaceuticals Laboratory, Asahi Chemical Industry Company, Ltd, Fuji-City, Shizuoka, Japan aut NATIONALLICENCE 700 1- Nagane T. Pharmacological Research Team, Life Science Research Laboratories, Asahi Chemical Industry Company, Ltd, Fuji-City, Shizuoka, Japan aut NATIONALLICENCE 700 1- Sugawara T. Pharmacological Research Team, Life Science Research Laboratories, Asahi Chemical Industry Company, Ltd, Fuji-City, Shizuoka, Japan aut NATIONALLICENCE 700 1- Oh-ishi J. Pharmacological Research Team, Life Science Research Laboratories, Asahi Chemical Industry Company, Ltd, Fuji-City, Shizuoka, Japan aut NATIONALLICENCE 700 1- Hayashi H. Pharmaceuticals Laboratory, Asahi Chemical Industry Company, Ltd, Fuji-City, Shizuoka, Japan aut NATIONALLICENCE 700 1- Watanabe N. Department of Internal Medicine (Section 4), Sapporo Medical College, Chuo-ku, Sapporo, Japan aut NATIONALLICENCE 700 1- Niitsu Y. Department of Internal Medicine (Section 4), Sapporo Medical College, Chuo-ku, Sapporo, Japan aut NATIONALLICENCE 773 0- Archives of Dermatological Research Springer-Verlag 282/7(1990-10-01), 459-462 0340-3696 282:7<459 1990 282 403 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer