caa a22 4500 465773273 CHVBK 20180323111935.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF00402624 doi (NATIONALLICENCE)springer-10.1007/BF00402624 Transdermal delivery of 5-fluorouracil through skin of hairless mice and humans in vitro: a comparison of the effect of formulations and a prodrug [Elektronische Daten] [E. Sherertz, K. Sloan, R. McTiernan] Summary: A 2% commercial solution formulation of 5-fluorouracil (5-FU) was significantly better at delivering 5-FU than either a 1% or 5% solution. Among single component suspension formulations the highest transdermal delivery was obtained from the vehicle in which 5-FU was least soluble, isopropyl myristate (IPM), while changes in the total suspended concentration of 5-FU in propyleneglycol (PG) had no significant effect on transdermal delivery by those suspensions. A prodrug of 5-FU/IPM was significantly better at delivering 5-FU than any of the formulations. The trends in relative rates of delivery of 5-FU by the formulations and the prodrug were the same in skin of hairless mice and humans. The mouse skin was about ten times more permeable than the human skin. Second application studies to assess skin damage caused by the formulations also showed the same trend in skin of hairless mice and humans: all of the formulations caused some damage. Springer-Verlag, 1990 Transdermal delivery nationallicence Isopropyl myristate nationallicence Skin nationallicence Diffusion cell experiment nationallicence 5-Fluorouracil (prodrug of 5-FU) nationallicence Sherertz E. Department of Medicine, Veterans Administration Medical Center (Research Service) and University of Florida, Gainesville, Florida aut Sloan K. Department of Medicinal Chemistry, University of Florida, Gainesville, Florida aut McTiernan R. Veterans Administration Medical Center, (Research Service), Gainesville, Florida, USA aut Archives of Dermatological Research Springer-Verlag 282/7(1990-10-01), 463-468 0340-3696 282:7<463 1990 282 403 https://doi.org/10.1007/BF00402624 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00402624 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sherertz E. Department of Medicine, Veterans Administration Medical Center (Research Service) and University of Florida, Gainesville, Florida aut NATIONALLICENCE 700 1- Sloan K. Department of Medicinal Chemistry, University of Florida, Gainesville, Florida aut NATIONALLICENCE 700 1- McTiernan R. Veterans Administration Medical Center, (Research Service), Gainesville, Florida, USA aut NATIONALLICENCE 773 0- Archives of Dermatological Research Springer-Verlag 282/7(1990-10-01), 463-468 0340-3696 282:7<463 1990 282 403 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer