caa a22 4500 465773303 CHVBK 20180323111935.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF00402618 doi (NATIONALLICENCE)springer-10.1007/BF00402618 Dynamic ultrastructural changes of the connective tissue sheath of human hair follicles during hair cycle [Elektronische Daten] [M. Ito, Y. Sato] Summary: Ultrastructural changes of the connective tissue sheath (CTS), including the hyaline membrane, of human hair follicles during the hair cycle, were studied in normal scalp skin specimens. In early anagen, the CTS was composed of a thin basal lamina and surrounding collagen tissue. The collagen tissue gradually thickened during the development of the hair and hair follicle. In mature anagen hair follicles, the collagen tissue was separated into three layers. The inner collagen layer, just outside the basal lamina, was thin and composed of collagen fibres running longitudinally parallel to the hair axis. The middle collagen layer was very thick with its collagen fibres running transversely against the hair axis and surrounding the inner hair tissue. Many fibroblasts were present among the collagen fibres in the middle layer, whereas the inner layer contained almost none. In the outer collagen layer, collagen fibres ran in various directions parallel to the outer surface of the outer root sheath cells. In late anagen, the basal lamina became very thick. In catagen, the basal lamine and the inner collagen layer became corrugated and showed oedematous change and degeneration. Surrounding fibroblasts showed active production of new collagen fibres, which seemed to fill the spaces left by the retraction of the hair follicle and hyaline membrane. These ultrastructural changes of the CTS show that there may be dynamic metabolic changes of the connective tissue around human hair follicles during the hair cycle. Springer-Verlag, 1990 Hair cycle nationallicence Human hair follicle nationallicence Connective tissue sheath nationallicence Hyaline membrane nationallicence Ultrastructure nationallicence Ito M. Department of Dermatology, Niigata University School of Medicine, 951, Niigata, Japan aut Sato Y. Department of Dermatology, Niigata University School of Medicine, 951, Niigata, Japan aut Archives of Dermatological Research Springer-Verlag 282/7(1990-10-01), 434-441 0340-3696 282:7<434 1990 282 403 https://doi.org/10.1007/BF00402618 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00402618 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ito M. Department of Dermatology, Niigata University School of Medicine, 951, Niigata, Japan aut NATIONALLICENCE 700 1- Sato Y. Department of Dermatology, Niigata University School of Medicine, 951, Niigata, Japan aut NATIONALLICENCE 773 0- Archives of Dermatological Research Springer-Verlag 282/7(1990-10-01), 434-441 0340-3696 282:7<434 1990 282 403 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer