caa a22 4500 465773419 CHVBK 20180323111935.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF00372622 doi (NATIONALLICENCE)springer-10.1007/BF00372622 Epinephrine synthesis in rat skin by an N -methyltransferase [Elektronische Daten] [H. Elayan, B. Kennedy, M. Ziegler] Summary: Homogenates of rat skin N-methylated norepinephrine to form epinephrine. In the brain and adrenal medulla the enzyme phenylethanolamine-N-methyltransferase synthesizes epinephrine, but the skin epinephrine forming enzyme was an N-methyltransferase distinct from phenylethanolamine-N-methyltransferase. Skin N-methyltransferase was not inhibited by the phenylethanolamine-N-methyltransferase inhibitor SKF 29661. Unlike phenylethanolamine-N-methyltransferase, skin readily methylated dopamine to form epinine. Sympathetic denervation by superior cervical ganglionectomy had no effect on skin N-methyltransferase levels. Procedures that reduced skin norepinephrine levels to 2% of control left skin epinephrine levels at 38% of control even when plasma epinephrine levels were very low. Skin contains an extraneuronal enzyme that synthesizes epinephrine in vitro and appears to synthesize part of the epinephrine normally present in skin. The enzyme can synthesize epinephrine and epinine, both of which can regulate epidermal proliferation, skin blood flow, and atopic responses. Springer-Verlag, 1990 Epinephrine nationallicence Skin phenylethanolamine- N -methyltransferase nationallicence Elayan H. Department of Medicine, Division of Nephrology, University of California San Diego Medical Center, USA aut Kennedy B. Department of Medicine, Division of Nephrology, University of California San Diego Medical Center, USA aut Ziegler M. Department of Medicine, Division of Nephrology, University of California San Diego Medical Center, USA aut Archives of Dermatological Research Springer-Verlag 282/3(1990-05-01), 194-197 0340-3696 282:3<194 1990 282 403 https://doi.org/10.1007/BF00372622 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00372622 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Elayan H. Department of Medicine, Division of Nephrology, University of California San Diego Medical Center, USA aut NATIONALLICENCE 700 1- Kennedy B. Department of Medicine, Division of Nephrology, University of California San Diego Medical Center, USA aut NATIONALLICENCE 700 1- Ziegler M. Department of Medicine, Division of Nephrology, University of California San Diego Medical Center, USA aut NATIONALLICENCE 773 0- Archives of Dermatological Research Springer-Verlag 282/3(1990-05-01), 194-197 0340-3696 282:3<194 1990 282 403 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer