caa a22 4500 465773435 CHVBK 20180323111935.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF00372619 doi (NATIONALLICENCE)springer-10.1007/BF00372619 Immunohistochemical detection of heterophile Hanganutziu-Deicher antigen in human malignant melanoma [Elektronische Daten] [T. Saida, S. Ikegawa, Y. Takizawa, S. Kawachi] Summary: The Hanganutziu-Deicher (HD) antigen is a heterophile antigen whose immunodominant molecule is N-glycolylneuraminic acid, a sialic acid that cannot be found in normal tissues of either humans or chickens. Using biotinylated chicken anti-HD antibody purified with affinity chromatography, expression of HD antigen was immunohistochemically investigated in formalin-fixed tissues of human malignant melanoma. HD antigen-positive melanoma cells were clearly demonstrated in 7 of 11 lesions of malignant melanoma. No HD antigen-positive cells were found in 8 lesions of melanocytic nevus, and no components of normal human skin including epidermal melanocytes were stained with the antibody. This study is the first that immunohistochemically demonstrates HD antigen in tissue sections of human malignant melanoma. The expression of the HD antigen in transformed human melanocytes may have great immunological significance because the antigen is absent from normal human tissues and is immunogenic in humans. Springer-Verlag, 1990 Human malignant melanoma nationallicence Hanganutziu-Deicher antigen nationallicence N -Glycolylneuraminic acid nationallicence Immunohistochemistry nationallicence Saida T. Department of Dermatology, Shinshu University School of Medicine, 3-1-1 Asahi, 390, Matsumoto, Japan aut Ikegawa S. Department of Dermatology, Shinshu University School of Medicine, 3-1-1 Asahi, 390, Matsumoto, Japan aut Takizawa Y. Department of Dermatology, Shinshu University School of Medicine, 3-1-1 Asahi, 390, Matsumoto, Japan aut Kawachi S. Department of Dermatology, Shinshu University School of Medicine, 3-1-1 Asahi, 390, Matsumoto, Japan aut Archives of Dermatological Research Springer-Verlag 282/3(1990-05-01), 179-182 0340-3696 282:3<179 1990 282 403 https://doi.org/10.1007/BF00372619 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00372619 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Saida T. Department of Dermatology, Shinshu University School of Medicine, 3-1-1 Asahi, 390, Matsumoto, Japan aut NATIONALLICENCE 700 1- Ikegawa S. Department of Dermatology, Shinshu University School of Medicine, 3-1-1 Asahi, 390, Matsumoto, Japan aut NATIONALLICENCE 700 1- Takizawa Y. Department of Dermatology, Shinshu University School of Medicine, 3-1-1 Asahi, 390, Matsumoto, Japan aut NATIONALLICENCE 700 1- Kawachi S. Department of Dermatology, Shinshu University School of Medicine, 3-1-1 Asahi, 390, Matsumoto, Japan aut NATIONALLICENCE 773 0- Archives of Dermatological Research Springer-Verlag 282/3(1990-05-01), 179-182 0340-3696 282:3<179 1990 282 403 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer