caa a22 4500 465773478 CHVBK 20180323111935.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF00372613 doi (NATIONALLICENCE)springer-10.1007/BF00372613 Interleukin 2, soluble interleukin 2 receptor, and interferon-γ in the suction blister fluids from psoriatic skin [Elektronische Daten] [H. Takematsu, H. Tagami] Summary: Psoriasis represents inflammatory skin disorders characterized by significant changes in cellular immunity, particularly exhibiting alterations in T lymphocyte-related functions. Early psoriatic lesions have been reported to show an infiltration of activated helper T cells. Elevated levels of interleukin 2 (IL-2), IL-2 receptor (IL-2R), and interferon-γ (INF-γ) are associated with an early activation of T cells. To examine local activation of T cells in psoriatic skin, the amounts of activated T cell products, IL-2, secretory form of IL-2R (sIL-2R) and INF-γ were measured in the fluids of suction blisters raised on psoriatic skin. sIL-2R levels were significantly elevated in the suction blister fluids raised on psoriatic involved skin compared with those on normal and psoriatic uninvolved skin. On the other hand, neither IL-2 or IFN-γ was detected in the suction blister fluids either from normal, psoriatic uninvolved, or involved skin. However, we could detect IFN-γ and IL-2 in the psoriatic scale extracts. Although we failed to detect IL-2 and IFN-γ in the suction blister fluids, the increased levels of sIL-2R in the suction blister fluids from the psoriatic lesional skin indicate local activation of T cells in psoriatic lesional skin. Springer-Verlag, 1990 Psoriasis nationallicence Interleukin 2 nationallicence Interleukin 2 receptor nationallicence Interferon-γ nationallicence Takematsu H. Department of Dermatology, Tohoku University School of Medicine, 1-1 Seiryo-machi, 980, Sendai, Japan aut Tagami H. Department of Dermatology, Tohoku University School of Medicine, 1-1 Seiryo-machi, 980, Sendai, Japan aut Archives of Dermatological Research Springer-Verlag 282/3(1990-05-01), 149-152 0340-3696 282:3<149 1990 282 403 https://doi.org/10.1007/BF00372613 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00372613 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takematsu H. Department of Dermatology, Tohoku University School of Medicine, 1-1 Seiryo-machi, 980, Sendai, Japan aut NATIONALLICENCE 700 1- Tagami H. Department of Dermatology, Tohoku University School of Medicine, 1-1 Seiryo-machi, 980, Sendai, Japan aut NATIONALLICENCE 773 0- Archives of Dermatological Research Springer-Verlag 282/3(1990-05-01), 149-152 0340-3696 282:3<149 1990 282 403 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer