caa a22 4500 465773613 CHVBK 20180323111935.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF00371639 doi (NATIONALLICENCE)springer-10.1007/BF00371639 Histamine metabolism in delayed type hypersensitivity — Comparative analysis with cellular infiltrates [Elektronische Daten] [T. Tachibana, K. Toda, F. Furukawa, S. Taniguchi, S. Imamura] Summary: We examined the dynamic changes of histamine metabolism and infiltrating cell populations in lesional sites of representative cutaneous delayed type hypersensitivity (DTH), including dinitrochlorobenzene (DNCB) allergic dermatitis, purified protein derivative of tuberculin (PPD) reaction, and keyhole limpet homocyanin (KLH)-induced cutaneous basophil hypersensitivity. The concentration of histamine increased with time in all DTH reactions examined, though the time course varied among these reactions. In DNCB allergic dermatitis, the maximum content of the amine at 3 days after the initiation was about three times that of the control baseline. In PPD reaction, the maximum content and the time course were almost similar to that in DNCB allergic dermatitis. However, in KLH-induced cutaneous basophil hypersensitivity the maximum content was about ten times that in DNCB allergic dermatitis or PPD reaction, and was observed earlier, on the 2nd day. There was no remarkable change in the activities of histamine-degrading enzymes in these reactions. There was little infiltration of mast cells, while time-dependent changes of the basophil infiltration were almost parallel those of the histamine concentration in all these reactions. Basophils in DNCB allergic dermatitis showed a piecemeal degranulation, while those in either the PPD reaction or KLH-induced cutaneous basophil hypersensitivity remained intact. These results clearly suggest that the increase of histamine concentration in cutaneous DTH depends on the number of basophils infiltrating the lesional sites, even if the regulatory mechanisms of the activation of the cells differ among the DTH reactions. Springer-Verlag, 1990 Histamine nationallicence Delayed type hypersensitivity nationallicence Basophil nationallicence Mast cells nationallicence Tachibana T. Department of Dermatology, Faculty of Medicine, Kyoto University, Sakyo, 606, Kyoto, Japan aut Toda K. Department of Dermatology, Faculty of Medicine, Kyoto University, Sakyo, 606, Kyoto, Japan aut Furukawa F. Department of Dermatology, Faculty of Medicine, Kyoto University, Sakyo, 606, Kyoto, Japan aut Taniguchi S. Department of Dermatology, Faculty of Medicine, Kyoto University, Sakyo, 606, Kyoto, Japan aut Imamura S. Department of Dermatology, Faculty of Medicine, Kyoto University, Sakyo, 606, Kyoto, Japan aut Archives of Dermatological Research Springer-Verlag 282/4(1990-06-01), 217-222 0340-3696 282:4<217 1990 282 403 https://doi.org/10.1007/BF00371639 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00371639 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tachibana T. Department of Dermatology, Faculty of Medicine, Kyoto University, Sakyo, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Toda K. Department of Dermatology, Faculty of Medicine, Kyoto University, Sakyo, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Furukawa F. Department of Dermatology, Faculty of Medicine, Kyoto University, Sakyo, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Taniguchi S. Department of Dermatology, Faculty of Medicine, Kyoto University, Sakyo, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Imamura S. Department of Dermatology, Faculty of Medicine, Kyoto University, Sakyo, 606, Kyoto, Japan aut NATIONALLICENCE 773 0- Archives of Dermatological Research Springer-Verlag 282/4(1990-06-01), 217-222 0340-3696 282:4<217 1990 282 403 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer