caa a22 4500 465773710 CHVBK 20180323111936.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF00371949 doi (NATIONALLICENCE)springer-10.1007/BF00371949 Antibodies against retroviral core proteins in relation to disease outcome in patients with mycosis fungoides [Elektronische Daten] [A. Ranki, K. Niemi, P. Nieminen, K. Krohn] Summary: We have studied the relationship of antibodies reacting with human retroviral core proteins to the disease outcome in Finnish mycosis fungoides (MF) patients in a prospective manner. Antibodies recognizing human T-cell leukaemia/lymphoma virus I (HTLV-I) or human immunodeficiency virus type 1 (HIV-1) core proteins were found in 12 of 14 MF patients as shown by the Western blot method. The antibody reactivities showed three patterns: three patients had antibodies cross-reacting with the gag-encoded core proteins of both HTLV-I and HIV-1; seven patients showed antibodies reacting with HTLV-I core proteins only; and the sera of two patients reacted with HIV p24 core protein only. When following the clinical course of these patients, we found that the three patients with antibodies cross-reacting with both viruses had the most fulminant clinical course, and the overall duration of MF was, on average, 4 years less than in the rest of the patients. None of the patients, however, became leukaemic, or showed any other features suggestive of acute T-cell leukaemia/lymphoma (ATL). Two patients, who did not show anti-retroviral antibodies during the follow-up, had a stable disease with plaque-type skin lesions. Histological or immunohistological typing of the skin infiltrates did not correlate with the disease outcome or the above antibody patterns. Our results thus raise the possibility that an unknown retrovirus, immunologically related to the known human retroviruses, may be aetiologically linked to MF. Springer-Verlag, 1990 Mycosis fungoides nationallicence Cutaneous T-cell lymphoma nationallicence HTLV-I nationallicence HIV-1 nationallicence Antibodies nationallicence Western blot nationallicence Ranki A. Department of Dermatology, Helsinki University Central Hospital, Snellmaninkatu 14, SF-00170, Helsinki, Finland aut Niemi K. Department of Dermatology, Helsinki University Central Hospital, Snellmaninkatu 14, SF-00170, Helsinki, Finland aut Nieminen P. Department of Pathology, University of Helsinki, Helsinki aut Krohn K. Institute of Biomedical Sciences, University of Tampere, Tampere, Finland aut Archives of Dermatological Research Springer-Verlag 282/8(1990-12-01), 532-538 0340-3696 282:8<532 1990 282 403 https://doi.org/10.1007/BF00371949 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00371949 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ranki A. Department of Dermatology, Helsinki University Central Hospital, Snellmaninkatu 14, SF-00170, Helsinki, Finland aut NATIONALLICENCE 700 1- Niemi K. Department of Dermatology, Helsinki University Central Hospital, Snellmaninkatu 14, SF-00170, Helsinki, Finland aut NATIONALLICENCE 700 1- Nieminen P. Department of Pathology, University of Helsinki, Helsinki aut NATIONALLICENCE 700 1- Krohn K. Institute of Biomedical Sciences, University of Tampere, Tampere, Finland aut NATIONALLICENCE 773 0- Archives of Dermatological Research Springer-Verlag 282/8(1990-12-01), 532-538 0340-3696 282:8<532 1990 282 403 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer