caa a22 4500 46577377X CHVBK 20180323111936.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF00371944 doi (NATIONALLICENCE)springer-10.1007/BF00371944 Basement membrane zone as a target for human neutrophil elastase in psoriasis [Elektronische Daten] [W. Glinski, M. Jarzabek-Chorzelska, M. Kuligowski, M. Pierozynska-Dubowska, M. Glinska-Ferenz, S. Jabłonska] Summary: Human neutrophil elastase was found, by indirect immunofluorescence using rabbit anti-elastase antiserum, to be bound to basement membrane of psoriatic plaques in vivo. The enzyme was also identified inside the migrating neutrophils in the reticular dermis and dermal papillae, as well as outside the cells in micro-abscesses in psoriatic skin. In vitro incubation of normal skin with human neutrophil elastase resulted in the destruction of hemidesmosomes and separation of the epidermis from the dermis above localizations of bullous pemphigoid antigen. These findings are direct evidence that human neutrophil elastase could play a role in psoriasis in in vivo destruction of the epidermal — dermal junction. Springer-Verlag, 1990 Psoriasis nationallicence Neutrophil elastase nationallicence Basement membrane nationallicence Glinski W. Department of Dermatology, Warsaw School of Medicine, 82A Koszykowa Street, PL-02008, Warsaw, Poland aut Jarzabek-Chorzelska M. Department of Dermatology, Warsaw School of Medicine, 82A Koszykowa Street, PL-02008, Warsaw, Poland aut Kuligowski M. Department of Dermatology, Warsaw School of Medicine, 82A Koszykowa Street, PL-02008, Warsaw, Poland aut Pierozynska-Dubowska M. Department of Dermatology, Warsaw School of Medicine, 82A Koszykowa Street, PL-02008, Warsaw, Poland aut Glinska-Ferenz M. Department of Dermatology, Warsaw School of Medicine, 82A Koszykowa Street, PL-02008, Warsaw, Poland aut Jabłonska S. Department of Dermatology, Warsaw School of Medicine, 82A Koszykowa Street, PL-02008, Warsaw, Poland aut Archives of Dermatological Research Springer-Verlag 282/8(1990-12-01), 506-511 0340-3696 282:8<506 1990 282 403 https://doi.org/10.1007/BF00371944 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00371944 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Glinski W. Department of Dermatology, Warsaw School of Medicine, 82A Koszykowa Street, PL-02008, Warsaw, Poland aut NATIONALLICENCE 700 1- Jarzabek-Chorzelska M. Department of Dermatology, Warsaw School of Medicine, 82A Koszykowa Street, PL-02008, Warsaw, Poland aut NATIONALLICENCE 700 1- Kuligowski M. Department of Dermatology, Warsaw School of Medicine, 82A Koszykowa Street, PL-02008, Warsaw, Poland aut NATIONALLICENCE 700 1- Pierozynska-Dubowska M. Department of Dermatology, Warsaw School of Medicine, 82A Koszykowa Street, PL-02008, Warsaw, Poland aut NATIONALLICENCE 700 1- Glinska-Ferenz M. Department of Dermatology, Warsaw School of Medicine, 82A Koszykowa Street, PL-02008, Warsaw, Poland aut NATIONALLICENCE 700 1- Jabłonska S. Department of Dermatology, Warsaw School of Medicine, 82A Koszykowa Street, PL-02008, Warsaw, Poland aut NATIONALLICENCE 773 0- Archives of Dermatological Research Springer-Verlag 282/8(1990-12-01), 506-511 0340-3696 282:8<506 1990 282 403 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer