caa a22 4500 465773834 CHVBK 20180323111936.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF00375724 doi (NATIONALLICENCE)springer-10.1007/BF00375724 Desmosomes, corneosomes and desquamation. An ultrastructural study of adult pig epidermis [Elektronische Daten] [S. Chapman, A. Walsh] Summary: We recently developed a pig skin model to determine the role of corneosomes (modified desmosomes in the stratum corneum) and extracellular lipids in desquamation. The present study provides control morphometric data on the morphological changes in desmosomes and corneosomes leading to desquamation in adult pig epidermis in vivo. The extracellular space within desmosomes gradually widened from the basal to the granular layer, and decreased slightly in the stratum corneum. Mid-dense line broadening, and increased electron density of the distal light layers, coincided with membrane-coating granule extrusion in the outer granular layer. Corneocyte attachment correlated with corneosome distribution. Compactum packing was relatively tight and corneosomes were numerous. Cohesion was mainly peripheral in the disjunctum, and corneosomes were restricted to corneocyte edges. Adhesion had a tongue-and-groove appearance with corneosomes riveting corneocyte peripheries into a lipped groove on adjoining cells. Cells shed by peeling radially towards the lipped groove, and corneosomes decreased from lower to upper disjunctum. Corneosome breakdown commenced with an electron lucent band forming between the plug and lipid envelope. The plug was then unzipped from the lipid envelope and degraded. Corneosomes did not form squamosomes. Springer-Verlag, 1990 Stratum corneum nationallicence Desmosomes nationallicence Corneosomes nationallicence Desquamation nationallicence Chapman S. Department of Dermatology, Royal Liverpool Hospital, Prescot Street, L69 3BX, Liverpool, UK aut Walsh A. Department of Dermatology, Royal Liverpool Hospital, Prescot Street, L69 3BX, Liverpool, UK aut Archives of Dermatological Research Springer-Verlag 282/5(1990-08-01), 304-310 0340-3696 282:5<304 1990 282 403 https://doi.org/10.1007/BF00375724 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00375724 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chapman S. Department of Dermatology, Royal Liverpool Hospital, Prescot Street, L69 3BX, Liverpool, UK aut NATIONALLICENCE 700 1- Walsh A. Department of Dermatology, Royal Liverpool Hospital, Prescot Street, L69 3BX, Liverpool, UK aut NATIONALLICENCE 773 0- Archives of Dermatological Research Springer-Verlag 282/5(1990-08-01), 304-310 0340-3696 282:5<304 1990 282 403 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer