caa a22 4500 465773877 CHVBK 20180323111936.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF00375721 doi (NATIONALLICENCE)springer-10.1007/BF00375721 UVA-induced tumours in pigmented hairless mice and the carcinogenic risks of tanning with UVA [Elektronische Daten] [H. van Weelden, S. van der Putte, J. Toonstra, J. van der Leun] Summary: An animal experiment is presented in which two groups of pigmented hairless mice were exposed daily to suberythemal doses of UVA to study tumourigenesis. The aim of the study was to estimate the carcinogenic risks of tanning by UVA. The pigmented hairless mice, Skh-hr2, were separated by selective breeding into two groups, the "browns” and the "blacks”. Both groups were exposed daily to UVA from fluorescent UVA lamps (Philips TL40W/09) purified by rigorously filtering out the shorter wavelengths. No acute actinic damage was observed after any exposure. However, in most UVA exposed animals, especially in the blacks, a marked scratching preceded the development of tumours. Hyperkeratosis was also observed. All animals developed tumours. Histopathologically at least 60% of the tumours were squamous cell carcinomas. Depositions of melanophages were observed, but no melanomas. It is beyond any doubt that UVA is carcinogenic in laboratory animals. The present state of knowledge justifies no preference for tanning with UVA over tanning with UVB. Springer-Verlag, 1990 UVA-radiation nationallicence Tanning nationallicence Carcinogenesis nationallicence van Weelden H. Institute of Dermatology, State University Utrecht, Utrecht, The Netherlands aut van der Putte S. Institute of Pathology, State University Utrecht, Utrecht, The Netherlands aut Toonstra J. Institute of Dermatology, State University Utrecht, Utrecht, The Netherlands aut van der Leun J. Institute of Dermatology, State University Utrecht, Utrecht, The Netherlands aut Archives of Dermatological Research Springer-Verlag 282/5(1990-08-01), 289-294 0340-3696 282:5<289 1990 282 403 https://doi.org/10.1007/BF00375721 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00375721 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van Weelden H. Institute of Dermatology, State University Utrecht, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- van der Putte S. Institute of Pathology, State University Utrecht, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Toonstra J. Institute of Dermatology, State University Utrecht, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- van der Leun J. Institute of Dermatology, State University Utrecht, Utrecht, The Netherlands aut NATIONALLICENCE 773 0- Archives of Dermatological Research Springer-Verlag 282/5(1990-08-01), 289-294 0340-3696 282:5<289 1990 282 403 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer