caa a22 4500 465773923 CHVBK 20180323111936.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00493466 doi (NATIONALLICENCE)springer-10.1007/BF00493466 A family study of atopic dermatitis [Elektronische Daten] Clinical and genetic characteristics of 188 patients and 2,151 family members [W. Küster, M. Petersen, E. Christophers, M. Goos, W. Sterry] Summary: The history of 188 Caucasian patients with atopic dermatitis (AD) and of 2,151 family members has been analyzed. Of the AD patients 48% suffered from respiratory atopy (36% rhinitis, 28% asthma, and 15% both). AD showed by far the earliest onset of all atopic diseases: 50% of our patients had skin lesions before the age of 2 years and 60% before the age of 5 years. In contrast, symptoms of allergic asthma developed in 40% of AD patients before the age of 5 years in comparison with only 25% who had allergic rhinitis. AD affects females more frequently than males (male to female ratio 1∶1.5), regardless of whether additional respiratory atopies are present or not. In contrast, respiratory atopies develop more frequently in males than in females (male to female ratio 1.5∶1). Mothers with respiratory atopy more often have atopic children (26%) than do fathers with respiratory atopy (13%). Finally, risk figures for genetic counselling are given. In short, the general risk of developing AD (3%) and atopy (7%) increases by a factor of two with each first-degree family member already suffering from atopy. Springer-Verlag, 1990 Atopic dermatitis nationallicence Family study nationallicence Genetic recurrence risk nationallicence Genetic counselling nationallicence Küster W. Department of Dermatology, University of Düsseldorf, FRG aut Petersen M. Department of Dermatology, University of Kiel, FRG aut Christophers E. Department of Dermatology, University of Kiel, FRG aut Goos M. Department of Dermatology, University of Essen, FRG aut Sterry W. Department of Dermatology, University of Kiel, FRG aut Archives of Dermatological Research Springer-Verlag 282/2(1990-01-01), 98-102 0340-3696 282:2<98 1990 282 403 https://doi.org/10.1007/BF00493466 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00493466 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Küster W. Department of Dermatology, University of Düsseldorf, FRG aut NATIONALLICENCE 700 1- Petersen M. Department of Dermatology, University of Kiel, FRG aut NATIONALLICENCE 700 1- Christophers E. Department of Dermatology, University of Kiel, FRG aut NATIONALLICENCE 700 1- Goos M. Department of Dermatology, University of Essen, FRG aut NATIONALLICENCE 700 1- Sterry W. Department of Dermatology, University of Kiel, FRG aut NATIONALLICENCE 773 0- Archives of Dermatological Research Springer-Verlag 282/2(1990-01-01), 98-102 0340-3696 282:2<98 1990 282 403 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer