caa a22 4500 465774040 CHVBK 20180323111937.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF00493461 doi (NATIONALLICENCE)springer-10.1007/BF00493461 Bicomponent keratohyalin in normal human ridged skin [Elektronische Daten] [I. Kastl, I. Anton-Lamprecht] Summary: Up to now, bicomponent keratohyalin has only been described for rat epithelium and human intraepidermal sweat ducts and fetal nail organ cells. In normal human interductal epidermis, the keratohyalin appears homogeneous, osmiophilic and stellate in shape. Under pathological conditions, bicomponent keratohyalin has been observed in different palmoplantar keratoses and has therefore been thought to be associated with abnormal keratosis. We studied the keratinization process in normal human plantar epidermis, in which keratohyalin was found to exhibit several morphological differences as compared to that seen in non-ridged skin. The most striking feature was seen in upper granular cells, where the keratohyalin granules consisted of two components of differing electron density. The electron-dense component formed the main part of the composite granule and was found in the cytoplasm of lower and upper granular cells. The less-electron-dense component was attached to the main component and appeared in the cytoplasm of upper granular cells, forming the convex contact zone. No intranuclear osmiophilic inclusions were present. The respective electron densities of the two keratohyalin components of ridged skin were obviously different to that of the bicomponent keratohyalin granules seen in the epidermal sweat-duct cells of the same specimen. These findings indicate the presence of at least two different types of keratohyalin proteins in normal human ridged skin. They can be distinguished at the electron-microscope level and differ from the keratohyalin of human non-ridged skin as well as from bicomponent keratohyalin granules derived from human epidermal sweat-duct cells or from rat epithelium. Springer-Verlag, 1990 Bicomponent keratohyalin nationallicence Ridged skin nationallicence Keratinization nationallicence Sweat ducts nationallicence Electron microscopy nationallicence Kastl I. Institut für Ultrastrukturforschung der Haut, Hautklinik der Ruprecht-Karls-UniversitÄt Heidelberg, Heidelberg, Federal Republic of Germany aut Anton-Lamprecht I. Institut für Ultrastrukturforschung der Haut, Hautklinik der Ruprecht-Karls-UniversitÄt Heidelberg, Heidelberg, Federal Republic of Germany aut Archives of Dermatological Research Springer-Verlag 282/2(1990-01-01), 71-75 0340-3696 282:2<71 1990 282 403 https://doi.org/10.1007/BF00493461 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00493461 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kastl I. Institut für Ultrastrukturforschung der Haut, Hautklinik der Ruprecht-Karls-UniversitÄt Heidelberg, Heidelberg, Federal Republic of Germany aut NATIONALLICENCE 700 1- Anton-Lamprecht I. Institut für Ultrastrukturforschung der Haut, Hautklinik der Ruprecht-Karls-UniversitÄt Heidelberg, Heidelberg, Federal Republic of Germany aut NATIONALLICENCE 773 0- Archives of Dermatological Research Springer-Verlag 282/2(1990-01-01), 71-75 0340-3696 282:2<71 1990 282 403 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer