caa a22 4500 465777031 CHVBK 20180323111945.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF02764317 doi (NATIONALLICENCE)springer-10.1007/BF02764317 Capillary endothelial-cell mitogenic activity in experimental branch vein occlusion [Elektronische Daten] [Eugene de Juan, Einar Stefánsson, John Dickson] Since the 1940s, the major hypothesis regarding the stimulus for neovascularization occurring in diabetic retinopathy and other "ischemic” retinopathies has involved the release of a soluble angiogenic factor from the ischemic retina. We sought to test this by measuring the endothelial mitogenic activity that could be extracted from an ischemic retina caused by branch vein occlusion in the cat. We found that the extracable endothelial-cell mitogenic activity from normal retinal areas was similar to that in ischemic areas at 1, 2, and 7 days after the occlusion. In the area of occluded veins, the oxygen partial pressure was low (7±7 mm Hg) compared with the normal value (23±8 mm Hg). The data did not show any increase in soluble mitogenic factor release from the ischemic retina versus normal retinal areas under the conditions of this experiment. Springer-Verlag, 1990 de Juan Eugene Duke University Eye Center, Box 3802, 27710, Durham, NC, USA aut Stefánsson Einar Duke University Eye Center, Box 3802, 27710, Durham, NC, USA aut Dickson John Duke University Eye Center, Box 3802, 27710, Durham, NC, USA aut Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/1(1990-01-01), 191-194 0721-832X 228:1<191 1990 228 417 https://doi.org/10.1007/BF02764317 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02764317 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- de Juan Eugene Duke University Eye Center, Box 3802, 27710, Durham, NC, USA aut NATIONALLICENCE 700 1- Stefánsson Einar Duke University Eye Center, Box 3802, 27710, Durham, NC, USA aut NATIONALLICENCE 700 1- Dickson John Duke University Eye Center, Box 3802, 27710, Durham, NC, USA aut NATIONALLICENCE 773 0- Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/1(1990-01-01), 191-194 0721-832X 228:1<191 1990 228 417 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer