caa a22 4500 465777058 CHVBK 20180323111945.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF02764294 doi (NATIONALLICENCE)springer-10.1007/BF02764294 Immunohistochemical characterization of epithelial cells in human lacrimal glands [Elektronische Daten] II. Inflammatory and neoplastic lesions of lacrimal glands [Carl Wilk, Nadarajah Vigneswaran, Angelika Heese, Otto Hornstein, Gottfried Naumann] The distribution of cytokeratins (CK), actin, lactoferrin (Lf), lysozyme (Ly), vimentin and S-100 protein was immunohistochemically investigated in paraffin-embedded specimens of five inflammatory and five neoplastic lesions of lacrimal glands (LGs). Atrophic acini in dacryoadenitis reacted with antibodies (ABs) KL1 and Pkk1 (CK 7, 8, 17, 18) in a manner similar to ducts. Apart from myoepithelial cells and some luminal-duct cells, the remaining epithelia in dacryoadenitis were negative with AB 34βE12 (CK 5). The number of AB HHF35 (actin)-positive myoepithelial cells was not altered in dacryoadenitis. Epithelia in dacryoadenitis reacted weakly but consistently with Lf while revealing weak and inconsistent staining for Ly. Vimentin was negative in epithelial cells in dacryoadenitis except in one case. S-100 protein was detected only in epithelia of inflammatory major LGs. Epimyoepithelial islands in lymphoepithelial proliferation reacted variably for CKs, Lf, Ly and vimentin and remained negative for actin and S-100. In pleomorphic adenomas, neoplastic cells showing duct-like differentiation (luminal) reacted consistently with CK 7, 8, 17, 18 and S-100 protein and inconsistently with CK 5, Lf and Ly but remained negative for actin and vimentin. Other neoplastic cells (ovoid/peripheral cells) stained consistently for CK 5, vimentin and S-100 protein and focally for CK 7, 8, 17, 18, actin, Lf and Ly. Spindle-form neoplastic cells found in the stroma exhibited vimentin and S-100 protein and, less frequently, actin. Determination of these antigens in pleomorphic LG adenomas may help to evaluate their prognosis. Springer-Verlag, 1990 Wilk Carl Augenklinik mit Poliklinik der Universität Erlangen-Nürnberg, Schwabachanlage 6, D-8520, Erlangen, Federal Republic of Germany aut Vigneswaran Nadarajah Dermatologische Klinik und Poliklinik der Universität Erlangen-Nürnberg, Hartmannstrasse 14, D-8520, Erlangen, Federal Republic of Germany aut Heese Angelika Dermatologische Klinik und Poliklinik der Universität Erlangen-Nürnberg, Hartmannstrasse 14, D-8520, Erlangen, Federal Republic of Germany aut Hornstein Otto Dermatologische Klinik und Poliklinik der Universität Erlangen-Nürnberg, Hartmannstrasse 14, D-8520, Erlangen, Federal Republic of Germany aut Naumann Gottfried Augenklinik mit Poliklinik der Universität Erlangen-Nürnberg, Schwabachanlage 6, D-8520, Erlangen, Federal Republic of Germany aut Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/1(1990-01-01), 65-72 0721-832X 228:1<65 1990 228 417 https://doi.org/10.1007/BF02764294 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02764294 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wilk Carl Augenklinik mit Poliklinik der Universität Erlangen-Nürnberg, Schwabachanlage 6, D-8520, Erlangen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Vigneswaran Nadarajah Dermatologische Klinik und Poliklinik der Universität Erlangen-Nürnberg, Hartmannstrasse 14, D-8520, Erlangen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Heese Angelika Dermatologische Klinik und Poliklinik der Universität Erlangen-Nürnberg, Hartmannstrasse 14, D-8520, Erlangen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Hornstein Otto Dermatologische Klinik und Poliklinik der Universität Erlangen-Nürnberg, Hartmannstrasse 14, D-8520, Erlangen, Federal Republic of Germany aut NATIONALLICENCE 700 1- Naumann Gottfried Augenklinik mit Poliklinik der Universität Erlangen-Nürnberg, Schwabachanlage 6, D-8520, Erlangen, Federal Republic of Germany aut NATIONALLICENCE 773 0- Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/1(1990-01-01), 65-72 0721-832X 228:1<65 1990 228 417 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer