caa a22 4500 465777236 CHVBK 20180323111945.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF02764289 doi (NATIONALLICENCE)springer-10.1007/BF02764289 Intraocular penetration of rifampin after oral administration [Elektronische Daten] [Kai Wong, Donald D'Amico, Boo Oum, Pacita Baker, Kenneth Kenyon] Rifampin, the most potent anti-staphylococcal drug known, was examined for its penetration into the aqueous and vitreous of rabbits after a single oral dose of 150 mg, 300 mg, or 600 mg. Maximum levels after the 150 mg dose were achieved at 4 h and were 4.2 µg/ml in the aqueous and 2.2 µg/ml in the vitreous. After the 300 mg dose, maximum levels were also achieved at 4 h, and were 5.0 µg/ml in the aqueous and 2.6 µg/ml in the vitreous. The 600 mg dose produced maximum levels at 6 h after administration, with 20.0 µg/ml in the aqueous and 15.2 µg/ml in the vitreous. These levels exceed the mimimum inhibitory concentration for many microorganisms and suggest additional investigation into possible applications of systemic rifampin in the prophylaxis and treatment of bacterial endophthalmitis. Springer-Verlag, 1990 Wong Kai How Laboratory of Ophthalmology, Harvard Medical School, Boston, MA, USA aut D'Amico Donald How Laboratory of Ophthalmology, Harvard Medical School, Boston, MA, USA aut Oum Boo How Laboratory of Ophthalmology, Harvard Medical School, Boston, MA, USA aut Baker Pacita How Laboratory of Ophthalmology, Harvard Medical School, Boston, MA, USA aut Kenyon Kenneth Cornea Service of the Massachusetts Eye and Ear Infirmary, and the Department of Ophthalmology, Harvard Medical School, Boston, MA, USA aut Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/1(1990-01-01), 40-43 0721-832X 228:1<40 1990 228 417 https://doi.org/10.1007/BF02764289 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02764289 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wong Kai How Laboratory of Ophthalmology, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- D'Amico Donald How Laboratory of Ophthalmology, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Oum Boo How Laboratory of Ophthalmology, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Baker Pacita How Laboratory of Ophthalmology, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Kenyon Kenneth Cornea Service of the Massachusetts Eye and Ear Infirmary, and the Department of Ophthalmology, Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 773 0- Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/1(1990-01-01), 40-43 0721-832X 228:1<40 1990 228 417 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer