caa a22 4500 465777287 CHVBK 20180323111945.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF02764306 doi (NATIONALLICENCE)springer-10.1007/BF02764306 Intraocular pressure effects on optic nerve-head oxidative metabolism measured in vivo [Elektronische Daten] [Roger Novack, Einar Stefánsson, Diane Hatchell] The effects of acute intraocular pressure (IOP) on the reduction/oxidation ratio of cytochromea,a 3 were measured from intact cat optic nerve by microfiber reflection spectrophotometry. This enabled the real-time analysis of optic nerve-head oxidative metabolism following IOP or mean arterial pressure (MAP) changes. Findings included: (1) cytochromea,a 3 became more reduced and relative blood volume decreased at lower perfusion pressures, even at IOP of <20 mm Hg; (2) metabolic inhibition began at variable perfusion pressures but invariably progressed as perfusion pressure declined; and (3) increased IOP or decreased MAP caused metabolic inhibition. These findings demonstrate that: (1) optic nerve metabolic dysfunction is possible at low IOPs; (2) lowering IOP can reverse metabolic dysfunction; (3) the metabolic response is dependent on IOP and/or MAP changes; and (4) the metabolic inhibition is related to optic nerve ischemia. Springer-Verlag, 1990 Novack Roger The Duke University Eye Center and the Durham Veteran's Administration Medical Center, Box 302, 27710, Durham, NC, USA aut Stefánsson Einar The Duke University Eye Center and the Durham Veteran's Administration Medical Center, Box 302, 27710, Durham, NC, USA aut Hatchell Diane The Duke University Eye Center and the Durham Veteran's Administration Medical Center, Box 302, 27710, Durham, NC, USA aut Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/1(1990-01-01), 128-133 0721-832X 228:1<128 1990 228 417 https://doi.org/10.1007/BF02764306 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02764306 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Novack Roger The Duke University Eye Center and the Durham Veteran's Administration Medical Center, Box 302, 27710, Durham, NC, USA aut NATIONALLICENCE 700 1- Stefánsson Einar The Duke University Eye Center and the Durham Veteran's Administration Medical Center, Box 302, 27710, Durham, NC, USA aut NATIONALLICENCE 700 1- Hatchell Diane The Duke University Eye Center and the Durham Veteran's Administration Medical Center, Box 302, 27710, Durham, NC, USA aut NATIONALLICENCE 773 0- Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/1(1990-01-01), 128-133 0721-832X 228:1<128 1990 228 417 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 465777287 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer