caa a22 4500 465777422 CHVBK 20180323111946.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF00918491 doi (NATIONALLICENCE)springer-10.1007/BF00918491 Experimental study on the fractionation schedule for proton irradiation of uveal melanoma [Elektronische Daten] [Gregor Wollensak, Leonidas Zografos, Charles Perret, Emmanuel Egger, Hedi Fritz-Niggli] Greene melanoma in the anterior chamber of rabbits was irradiated by protons to find the isoeffect curve for proton irradiation fractionated into one, two, three or four doses. The isoeffect curve for tumor tissue remained constant between one- and three-dose fractionations and rose with four-dose fractionation. The isoeffect curve for normal tissue approximately followed the Ellis equation. Therefore, the optimal irradiation schedule should be in the range of three fractions because this best spares normal tissue while delivering a tumoricidal dose to the lesion. The relative reduction of the total dose from four- to one-dose fractions of intraoperative irradiation should be 20%. Springer-Verlag, 1990 Wollensak Gregor Strahlenbiologisches Institut der Universität Zürich, Switzerland aut Zografos Leonidas Hôpital Ophtalmique, Université de Lausanne, Switzerland aut Perret Charles Paul-Scherrer-Institute, Villigen, Switzerland aut Egger Emmanuel Paul-Scherrer-Institute, Villigen, Switzerland aut Fritz-Niggli Hedi Strahlenbiologisches Institut der Universität Zürich, Switzerland aut Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/6(1990-11-01), 562-568 0721-832X 228:6<562 1990 228 417 https://doi.org/10.1007/BF00918491 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00918491 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wollensak Gregor Strahlenbiologisches Institut der Universität Zürich, Switzerland aut NATIONALLICENCE 700 1- Zografos Leonidas Hôpital Ophtalmique, Université de Lausanne, Switzerland aut NATIONALLICENCE 700 1- Perret Charles Paul-Scherrer-Institute, Villigen, Switzerland aut NATIONALLICENCE 700 1- Egger Emmanuel Paul-Scherrer-Institute, Villigen, Switzerland aut NATIONALLICENCE 700 1- Fritz-Niggli Hedi Strahlenbiologisches Institut der Universität Zürich, Switzerland aut NATIONALLICENCE 773 0- Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/6(1990-11-01), 562-568 0721-832X 228:6<562 1990 228 417 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 439391148 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer