caa a22 4500 465777473 CHVBK 20180323111946.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF00918482 doi (NATIONALLICENCE)springer-10.1007/BF00918482 Taxol treatment of experimental proliferative vitreoretinopathy [Elektronische Daten] [Stewart Daniels, Kevin Coonley, Marc Yoshizumi] Taxol is a potent stabilizer of microtubules, and inhibitor of in vitro replication, migration, and contraction of fibroblasts. It has been found to limit the development of experimental tractional retinal detachments in nonvitrectomized rabbit eyes. We used taxol in vitrectomized, phakic rabbit eyes with experimentally induced proliferative vitreoretinopathy and tractional retinal detachments. Taxol was dissolved in 30% DMSO because of poor aqueous solubility. A single 0.1 ml intravitreal dose of 2 × 10−4 M taxol in 30% DMSO was injected immediately after 250000 heterologous corneal fibroblasts had been injected; 0.1 ml of 30% DMSO was injected into control eyes. Taxol reduced the incidence of tractional retinal detachments seen 3-4 weeks later. When taxol injection was delayed for 3 days after the initial intravitreal injection of fibroblasts into nonvitrectomized eyes, the extent of retinal detachments was reduced, but the incidence of retinal detachment was unchanged from the untreated eyes at the end of 4 weeks. These data indicate that taxol may be most useful when given early in the course of proliferative vitreoretinopathy. Springer-Verlag, 1990 Daniels Stewart Vitreoretinal Division, Jules Stein Eye Institute, University of California, Los Angeles, 200 Stein Plaza, 90024-7007, Los Angeles, CA, USA aut Coonley Kevin Vitreoretinal Division, Jules Stein Eye Institute, University of California, Los Angeles, 200 Stein Plaza, 90024-7007, Los Angeles, CA, USA aut Yoshizumi Marc Vitreoretinal Division, Jules Stein Eye Institute, University of California, Los Angeles, 200 Stein Plaza, 90024-7007, Los Angeles, CA, USA aut Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/6(1990-11-01), 513-516 0721-832X 228:6<513 1990 228 417 https://doi.org/10.1007/BF00918482 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00918482 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Daniels Stewart Vitreoretinal Division, Jules Stein Eye Institute, University of California, Los Angeles, 200 Stein Plaza, 90024-7007, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Coonley Kevin Vitreoretinal Division, Jules Stein Eye Institute, University of California, Los Angeles, 200 Stein Plaza, 90024-7007, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Yoshizumi Marc Vitreoretinal Division, Jules Stein Eye Institute, University of California, Los Angeles, 200 Stein Plaza, 90024-7007, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/6(1990-11-01), 513-516 0721-832X 228:6<513 1990 228 417 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer