caa a22 4500 465777503 CHVBK 20180323111946.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF00918486 doi (NATIONALLICENCE)springer-10.1007/BF00918486 Evaluation of polyvinyl alcohol hydrogel as a soft contact lens material [Elektronische Daten] [Mihori Kita, Yuichiro Ogura, Yoshihito Honda, Suong-Hyu Hyon, Won-II Cha, Yoshito Ikada] We prepared a transparent polyvinyl alcohol (PVA) hydrogel from a PVA solution in a mixed solvent consisting of water and a water-miscible organic solvent by cooling. The physical properties of the hydrogel were evaluated in various mixed solvents and compared with those of commercially available soft contact lens materials, such as polyhydroxyethyl methacrylate (PHEMA) and copolymers of methylmethycrylate (MMA) and N-vinyl pyrrolidone (N-VP). The PVA hydrogel showed higher tensile strength and elongation before breaking than did the other materials. Also, the PVA hydrogel was comparable in its high water content and its oxygen permeability with the MMA/VP copolymers. The protein adsorption of the PVA hydrogel was much lower than that of the other materials. Soft contact lenses of PVA hydrogel were applied to rabbit eyes for 12 weeks. The effects of the lenses on the cornea were studied by biomicroscopy, ultrasonic pachymetry, and histopathologic examination. No abnormal findings were noted, suggesting that the PVA hydrogel may be promising as a new material for use in soft contact lenses. Springer-Verlag, 1990 Kita Mihori Department of Ophthalmology, Faculty of Medicine, Kyoto University, 606, Sakyo-ku Kyoto, Japan aut Ogura Yuichiro Department of Ophthalmology, Faculty of Medicine, Kyoto University, 606, Sakyo-ku Kyoto, Japan aut Honda Yoshihito Department of Ophthalmology, Faculty of Medicine, Kyoto University, 606, Sakyo-ku Kyoto, Japan aut Hyon Suong-Hyu Research Center for Medical Polymers and Biomaterials, Kyoto University, Kyoto, Japan aut Cha Won-II Research Center for Medical Polymers and Biomaterials, Kyoto University, Kyoto, Japan aut Ikada Yoshito Research Center for Medical Polymers and Biomaterials, Kyoto University, Kyoto, Japan aut Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/6(1990-11-01), 533-537 0721-832X 228:6<533 1990 228 417 https://doi.org/10.1007/BF00918486 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00918486 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kita Mihori Department of Ophthalmology, Faculty of Medicine, Kyoto University, 606, Sakyo-ku Kyoto, Japan aut NATIONALLICENCE 700 1- Ogura Yuichiro Department of Ophthalmology, Faculty of Medicine, Kyoto University, 606, Sakyo-ku Kyoto, Japan aut NATIONALLICENCE 700 1- Honda Yoshihito Department of Ophthalmology, Faculty of Medicine, Kyoto University, 606, Sakyo-ku Kyoto, Japan aut NATIONALLICENCE 700 1- Hyon Suong-Hyu Research Center for Medical Polymers and Biomaterials, Kyoto University, Kyoto, Japan aut NATIONALLICENCE 700 1- Cha Won-II Research Center for Medical Polymers and Biomaterials, Kyoto University, Kyoto, Japan aut NATIONALLICENCE 700 1- Ikada Yoshito Research Center for Medical Polymers and Biomaterials, Kyoto University, Kyoto, Japan aut NATIONALLICENCE 773 0- Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/6(1990-11-01), 533-537 0721-832X 228:6<533 1990 228 417 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer