caa a22 4500 465777546 CHVBK 20180323111946.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF00920023 doi (NATIONALLICENCE)springer-10.1007/BF00920023 Irradiation cataract in children after bone marrow transplantation [Elektronische Daten] [Marjatta Lappi, Jukka Rajantie, Risto Uusitalo] Chemotherapy and radiation produce a dose-dependent anti-leukemic effect. Combined chemoradiotherapy and bone marrow transplantation (BMT) were given in our clinic to treat children with acute leukemias. Total body irradiation of 10 Gy in a single dose was used. One long-term side effect of this treatment was the development of subcapsular cataract; this was seen in all nine long-term survivors of the 17 children with acute lymphoblastic (ALL) or acute myelogenous (AML) leukemia who were treated as described above. One year after marrow transplantation, all the eyes studied had visual acuity of 20/20 and an optically clear lens. Three years later, 60% of the eyes had visual acuity of less than 20/40 and all had posterior, subcapsular cataracts. The cataract in all cases was quite uniform, consisting of opacities in the posterior subcapsular region. Cataract formation was treatment-related and seemed to correlate only to the type of total body irradiation. We concluded that the cataracts seen in the present study were a late complication of allogeneic BMT and were specifically due to the single-dose total body irradiation. Springer-Verlag, 1990 Lappi Marjatta Children's Hospital, Helsinki University Central Hospital, Haartmanink 4C, SF-00290, Helsinki, Finland aut Rajantie Jukka Children's Hospital, Helsinki University Central Hospital, Haartmanink 4C, SF-00290, Helsinki, Finland aut Uusitalo Risto Department of Ophthalmology, Helsinki University Central Hospital, Haartmanink 4C, SF-00290, Helsinki, Finland aut Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/3(1990-05-01), 218-221 0721-832X 228:3<218 1990 228 417 https://doi.org/10.1007/BF00920023 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00920023 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lappi Marjatta Children's Hospital, Helsinki University Central Hospital, Haartmanink 4C, SF-00290, Helsinki, Finland aut NATIONALLICENCE 700 1- Rajantie Jukka Children's Hospital, Helsinki University Central Hospital, Haartmanink 4C, SF-00290, Helsinki, Finland aut NATIONALLICENCE 700 1- Uusitalo Risto Department of Ophthalmology, Helsinki University Central Hospital, Haartmanink 4C, SF-00290, Helsinki, Finland aut NATIONALLICENCE 773 0- Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/3(1990-05-01), 218-221 0721-832X 228:3<218 1990 228 417 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer