caa a22 4500 465777562 CHVBK 20180323111946.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF00920033 doi (NATIONALLICENCE)springer-10.1007/BF00920033 Autoantibodies to retinal astrocytes associated with age-related macular degeneration [Elektronische Daten] [Philip Penfoldi, Jan Provis, Judith Furby, Paul Gatenby, Francis Billson] Sera from 128 patients with age-related macular degeneration (AMD) were examined and profiles of a variety of serum constituents, including immunoglobulins, alpha and beta globulins and autoantibodies, were tabulated. A similar series of tests were carried out on 20 control sera. The results indicate a higher incidence of serum abnormalities, particularly involving alpha-2 globulin, in patients with disturbance of pigmentation of the retinal pigment epithelium (RPE). The sera were further tested for the presence of autoantibodies with specificity for retinal tissue, and five major staining patterns were observed. Many sera produced patterns of labelling on human retina identical to that observed using labelled monoclonal anti-glial fibrillary acid protein (GFAP) antibodies, which are an established marker of retinal astrocytes. Although anti-retinal autoantibodies have been reported in association with a number of ocular pathologies, the observation of anti-astrocyte autoantibodies is new. Astrocytes are involved in the maintenance of the blood-retinal barrier (BRB) and also appear to be the facultative antigen-presenting cells of neural tissue. The present results indicate that the formation of anti-astrocyte autoantibodies may be an early feature of the pathogenesis of AMD. Springer-Verlag, 1990 Penfoldi Philip Save Sight and Eye Health Institute, Department of Clinical Ophthalmology, University of Sydney, Sydney, Australia aut Provis Jan Department of Anatomy, University of Sydney, Sydney, Australia aut Furby Judith Save Sight and Eye Health Institute, Department of Clinical Ophthalmology, University of Sydney, Sydney, Australia aut Gatenby Paul Department of Clinical Immunology, Royal Prince Alfred Hospital, Sydney, Australia aut Billson Francis Save Sight and Eye Health Institute, Department of Clinical Ophthalmology, University of Sydney, Sydney, Australia aut Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/3(1990-05-01), 270-274 0721-832X 228:3<270 1990 228 417 https://doi.org/10.1007/BF00920033 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00920033 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Penfoldi Philip Save Sight and Eye Health Institute, Department of Clinical Ophthalmology, University of Sydney, Sydney, Australia aut NATIONALLICENCE 700 1- Provis Jan Department of Anatomy, University of Sydney, Sydney, Australia aut NATIONALLICENCE 700 1- Furby Judith Save Sight and Eye Health Institute, Department of Clinical Ophthalmology, University of Sydney, Sydney, Australia aut NATIONALLICENCE 700 1- Gatenby Paul Department of Clinical Immunology, Royal Prince Alfred Hospital, Sydney, Australia aut NATIONALLICENCE 700 1- Billson Francis Save Sight and Eye Health Institute, Department of Clinical Ophthalmology, University of Sydney, Sydney, Australia aut NATIONALLICENCE 773 0- Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/3(1990-05-01), 270-274 0721-832X 228:3<270 1990 228 417 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer