caa a22 4500 465777570 CHVBK 20180323111946.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF00920030 doi (NATIONALLICENCE)springer-10.1007/BF00920030 Osmotic state of lenses in three dominant murine cataract mutants [Elektronische Daten] [Jochen Graw, Peter Reitmeir, Andrea Wulff] Three newly detected dominant cataract mutations (Asc-1, Cat-3 vao,Tcm) were investigated for effects on osmotic alterations in the lenses of heterozygotes. The lens wet weight was reduced in two mutant lines (Cat-3 vao andTcm), and the water content in the lenses of theCat-3 vao mice was increased. Moreover, in the cataractous lenses fromCat-3 vao mice, the sodium-potassium-adenosine triphosphatase (Na+ -K+-ATPase) activity was enhanced and the ATP concentration, correspondingly decreased. The osmotic variations observed in theCat-3 vao mutants might have been due to a metabolic response to the yet unknown, primary pathological event. The lenses of the other two mutant lines (Asc-1 andTcm) revealed no alterations that could be related to osmotic stress. In no mutant line investigated could a decrease in Na+-K+-ATPase activity be demonstrated that was similar to the causative factor in the Nakano mutant line. TheCat-3 vao mice exhibited some similarities to the Philly mutant line. Springer-Verlag, 1990 Graw Jochen GSF-Institut für Säugetiergenetik, Ingolstädter Landstrasse 1, D-8042, Neuherberg, Germany aut Reitmeir Peter GSF-Institut für Medizinische Informatik und Systemforschung, Ingolstädter Landstrasse 1, D-8042, Neuherberg, Germany aut Wulff Andrea GSF-Institut für Medizinische Informatik und Systemforschung, Ingolstädter Landstrasse 1, D-8042, Neuherberg, Germany aut Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/3(1990-05-01), 252-254 0721-832X 228:3<252 1990 228 417 https://doi.org/10.1007/BF00920030 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00920030 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Graw Jochen GSF-Institut für Säugetiergenetik, Ingolstädter Landstrasse 1, D-8042, Neuherberg, Germany aut NATIONALLICENCE 700 1- Reitmeir Peter GSF-Institut für Medizinische Informatik und Systemforschung, Ingolstädter Landstrasse 1, D-8042, Neuherberg, Germany aut NATIONALLICENCE 700 1- Wulff Andrea GSF-Institut für Medizinische Informatik und Systemforschung, Ingolstädter Landstrasse 1, D-8042, Neuherberg, Germany aut NATIONALLICENCE 773 0- Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/3(1990-05-01), 252-254 0721-832X 228:3<252 1990 228 417 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer