caa a22 4500 465777732 CHVBK 20180323111947.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF00920061 doi (NATIONALLICENCE)springer-10.1007/BF00920061 Ocular toxicity of multiple intravitreal DHPG injections [Elektronische Daten] [Marc Yoshizumi, David Lee, Virginia Vinci, Samantha Fajardo] Intravitreal 9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine (DHPG) has been advocated as an alternative mode of therapy in cytomegalovirus (CMV) retinitis in the acquired immunodeficiency syndrome (AIDS) because of toxic neutropenia which is a complication of systemic intravenous DHPG [7]. The recommended regimen requires injection of 200 \gmg DHPG intravitreally twice a week for a period of several weeks to months to control the progression of CMV retinitis [5, 14]. A previous study performed to determine the safe dose of intravitreal DHPG was based on a single intravitreal dose study [101; it does not consider the toxicity which may arise from multiple intravitreal injections of DHPG as it is utilized in the treatment of patients with CMV retinitis. In our study, intravitreal injections of 1000, 400, 200, 100, 50, and 25 \gmg DHPG were administered weekly for a period of 5 weeks in rabbit eyes. Ocular toxicity was monitored using slit-lamp biomicroscopy, indirect ophthalmoscopy, electroretinography, and light and electron microscopy. Electroretinographic evidence of retinal toxicity was found with doses as low as 100 \gmg. Electron-micrographic studies of retinal tissue from the eyes injected with even lower doses (as low as 25 \gmg) also showed evidence of toxic vacuolization in the inner segments of the photoreceptor. Springer-Verlag, 1990 Yoshizumi Marc Jules Stein Eye Institute, Retina Division, UCLA School of Medicine, 200 Stein Plaza, 90024-7007, Los Angeles, CA, USA aut Lee David Jules Stein Eye Institute, Retina Division, UCLA School of Medicine, 200 Stein Plaza, 90024-7007, Los Angeles, CA, USA aut Vinci Virginia Ospedale Oftalmico, Torino, Italy aut Fajardo Samantha Jules Stein Eye Institute, Retina Division, UCLA School of Medicine, 200 Stein Plaza, 90024-7007, Los Angeles, CA, USA aut Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/4(1990-07-01), 350-355 0721-832X 228:4<350 1990 228 417 https://doi.org/10.1007/BF00920061 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00920061 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yoshizumi Marc Jules Stein Eye Institute, Retina Division, UCLA School of Medicine, 200 Stein Plaza, 90024-7007, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Lee David Jules Stein Eye Institute, Retina Division, UCLA School of Medicine, 200 Stein Plaza, 90024-7007, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Vinci Virginia Ospedale Oftalmico, Torino, Italy aut NATIONALLICENCE 700 1- Fajardo Samantha Jules Stein Eye Institute, Retina Division, UCLA School of Medicine, 200 Stein Plaza, 90024-7007, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/4(1990-07-01), 350-355 0721-832X 228:4<350 1990 228 417 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer