caa a22 4500 465777740 CHVBK 20180323111947.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF00920051 doi (NATIONALLICENCE)springer-10.1007/BF00920051 The ophthalmic rod — a new drug-delivery system II [Elektronische Daten] [Safwat Alani, Wolfgang Hammerstein] The ophthalmic rod (OR) is a new ophthalmic drug-delivery system. The rod is made of nontoxic plastic. The active substance is deposited as a thin film on the end of the rod. To deliver the drug, the tip of the rod is introduced into the conjunctival sac and rubbed against the palpebral conjunctiva of the lower lid. The OR is a single-dose sterile applicator. By using the OR the problems of preservation and sterility of eyedrops are eliminated, and the risk of cross-infection is avoided. This was an open uncontrolled study. Clonidine ORs were used by 15 patients with glaucoma for 12 days. Fluorescein ORs were used for tonometry and to check the safetness of using the ORs. Patients with dry eyes or scotoma were excluded from the study. The clonidine film remaining on the ORs after delivery was quantitatively analyzed. A dose of 20 μg clonidine rod, three ORs/day, was sufficient to keep the ocular pressure under control. The fluorescin ORs, 30 μg/rod, were satisfactory for coloring the cornea. On the last day (12th) no clinically apparent side effects were observed. Subjectively, the patients were satisfied with the OR method of application, as an alternative to eyedrops. Springer-Verlag, 1990 Alani Safwat Universitäts-Augenklinik, Moorenstrasse 5, D-4000, Düsseldorf 1, Germany aut Hammerstein Wolfgang Universitäts-Augenklinik, Moorenstrasse 5, D-4000, Düsseldorf 1, Germany aut Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/4(1990-07-01), 302-304 0721-832X 228:4<302 1990 228 417 https://doi.org/10.1007/BF00920051 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00920051 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Alani Safwat Universitäts-Augenklinik, Moorenstrasse 5, D-4000, Düsseldorf 1, Germany aut NATIONALLICENCE 700 1- Hammerstein Wolfgang Universitäts-Augenklinik, Moorenstrasse 5, D-4000, Düsseldorf 1, Germany aut NATIONALLICENCE 773 0- Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/4(1990-07-01), 302-304 0721-832X 228:4<302 1990 228 417 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer