caa a22 4500 465777899 CHVBK 20180323111947.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF00920050 doi (NATIONALLICENCE)springer-10.1007/BF00920050 Alani Safwat Department of Ophthalmology, Sahlgrenś Hospital, University of Göteborg, Göteborg, Sweden aut The ophthalmic rod: A new ophthalmic drug delivery system I [Elektronische Daten] [Safwat Alani] The ophthalmic rod (OR) is a new drug delivery system, intended as an alternative to conventional therapy in ophthalmology. The rod is made of a nontoxic plastic. It is dipped into a drug solution which after drying forms a thin homogeneous coating. The OR is then packed and sterilized by gamma radiation. The effects of radiation on the contents of the drugs were studied using IR, UV, and thin-layer chromatography (TLC). Sterility, dose variation, and simulated drug delivery in vitro were tested. Pure drugs were used; no preservatives were included. To deliver the drug, the tip of the rod is introduced into the conjunctival sac and rubbed against the palpebral conjunctiva of the lower lid. ORs with tropicamide, oxybuprocaine HCl, pilocarpine HCl, and fluorescein sodium were used. The behavior of the drugs administered by this system was compared with eyedrops. Results of trials with three drugs, i.e., tropicamide, oxybuprocaine HCl, and fluorescein sodium on ORs applied to the eyes of humans and those of the rabbit are discussed. Springer-Verlag, 1990 Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/4(1990-07-01), 297-301 0721-832X 228:4<297 1990 228 417 https://doi.org/10.1007/BF00920050 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00920050 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Alani Safwat Department of Ophthalmology, Sahlgrenś Hospital, University of Göteborg, Göteborg, Sweden aut NATIONALLICENCE 773 0- Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/4(1990-07-01), 297-301 0721-832X 228:4<297 1990 228 417 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer