caa a22 4500 465777937 CHVBK 20180323111947.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF00927265 doi (NATIONALLICENCE)springer-10.1007/BF00927265 Toxicity and clearance of intravitreal cefotetan [Elektronische Daten] [Wolfgang Philipp, Kurt Schmid, Hans Steiner, Beata Pümpel, Franz Allerberger, Hans Aichberger, Wolfgang Mayer] Direct, intravitreal injection of antibiotics plays an important role in the management of bacterial endophthalmitis. In the present study we investigated the toxicity and clearance of intravitreally injected cefotetan in a rabbit model. No toxic ocular side effects could be detected by electroretinography (ERG) or light and electron microscopy up to and including a single intravitreal dose of 1000 μg. Intravitreal injection of 2000 μg cefotetan resulted in mild degeneration of photoreceptor outer segments and, sporadically, in cataract formation. After intravitreal injection of 4000 μg, moderate toxic degeneration of photoreceptors occurred, with displacement and mitochondrial swelling of inner segments. In addition, lysosomal lamellar inclusion bodies could be detected in pigment epithelial cells. After a single intravitreal injection of 1000 μg cefotetan, concentrations greater than the minimum necessary for the inhibition of most commonly occurring intraocular pathogens (exceptPseudomonas aeruginosa andStaphylococcus epidermidis) were maintained in the vitreous humor for > 48 h. Cefotetan may be a potentially important drug for intravitreal injection, especially in cases of gram-negative and suspected anaerobic endophthalmitis. Springer-Verlag, 1990 Philipp Wolfgang Universitäts-Klinik für Augenheilkunde, Anichstrasse 35, A-6020, Innsbruck, Austria aut Schmid Kurt Institut für pathologische Anatomic der Universität, Müllerstrasse 44, A-6020, Innsbruck, Austria aut Steiner Hans Institut für pathologische Anatomic der Universität, Müllerstrasse 44, A-6020, Innsbruck, Austria aut Pümpel Beata Universitäts-Klinik für Augenheilkunde, Anichstrasse 35, A-6020, Innsbruck, Austria aut Allerberger Franz Institut für Hygiene der Universitat, Fritz-Pregl-Strasse 3, A-6020, Innsbruck, Austria aut Aichberger Hans Universitäts-Klinik für Augenheilkunde, Anichstrasse 35, A-6020, Innsbruck, Austria aut Mayer Wolfgang Universitäts-Klinik für Augenheilkunde, Anichstrasse 35, A-6020, Innsbruck, Austria aut Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/5(1990-09-01), 475-480 0721-832X 228:5<475 1990 228 417 https://doi.org/10.1007/BF00927265 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00927265 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Philipp Wolfgang Universitäts-Klinik für Augenheilkunde, Anichstrasse 35, A-6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Schmid Kurt Institut für pathologische Anatomic der Universität, Müllerstrasse 44, A-6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Steiner Hans Institut für pathologische Anatomic der Universität, Müllerstrasse 44, A-6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Pümpel Beata Universitäts-Klinik für Augenheilkunde, Anichstrasse 35, A-6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Allerberger Franz Institut für Hygiene der Universitat, Fritz-Pregl-Strasse 3, A-6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Aichberger Hans Universitäts-Klinik für Augenheilkunde, Anichstrasse 35, A-6020, Innsbruck, Austria aut NATIONALLICENCE 700 1- Mayer Wolfgang Universitäts-Klinik für Augenheilkunde, Anichstrasse 35, A-6020, Innsbruck, Austria aut NATIONALLICENCE 773 0- Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/5(1990-09-01), 475-480 0721-832X 228:5<475 1990 228 417 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer