caa a22 4500 465778038 CHVBK 20180323111947.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF00927267 doi (NATIONALLICENCE)springer-10.1007/BF00927267 Ultrastructural pathology of anterior persistent hyperplastic primary vitreous [Elektronische Daten] [Manfred Spitznas, Frank Koch, Susanne Pohl] Using transmission electron microscopy, the fine structure of anterior persistent hyperplastic primary vitreous (PHPV) removed from the eyes of four infants was studied. The tissue mass was composed of vessels derived from or representing the tunica vasculosa lentis posterior and the vasa hyaloidea propria. They were embedded in a loose connective-tissue matrix containing many fibroblasts and mature collagen fibrils. Toward the posterior surface, the fibroblasts became more numerous, elongated and densely packed. At the point of its entry into the posterior pole of the mass, the hyaloid artery was found to be surrounded by glial cells, probably representing an extension of the wall cells of the hyaloid canal. Venous drainage of the PHPV nodules seemed to occur via the ciliary body to which they were connected by tiny vessels bridging the distance from the PHPV lump to elongated ciliary processes. The anterior surface of the tissue lump was covered with lens fragments. These remnants showed signs of very early disturbance of lens development, with a failure to form posterior lens fibers. Based on these findings, the authors sugget that PHPV may be secondary to a primary defect in lens development. Springer-Verlag, 1990 Spitznas Manfred Alfried Krupp Labor, Universitäts-Augenklinik, Sigmund-Freud-Strasse 25, D-5300, Bonn, Germany aut Koch Frank Alfried Krupp Labor, Universitäts-Augenklinik, Sigmund-Freud-Strasse 25, D-5300, Bonn, Germany aut Pohl Susanne Alfried Krupp Labor, Universitäts-Augenklinik, Sigmund-Freud-Strasse 25, D-5300, Bonn, Germany aut Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/5(1990-09-01), 487-496 0721-832X 228:5<487 1990 228 417 https://doi.org/10.1007/BF00927267 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00927267 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Spitznas Manfred Alfried Krupp Labor, Universitäts-Augenklinik, Sigmund-Freud-Strasse 25, D-5300, Bonn, Germany aut NATIONALLICENCE 700 1- Koch Frank Alfried Krupp Labor, Universitäts-Augenklinik, Sigmund-Freud-Strasse 25, D-5300, Bonn, Germany aut NATIONALLICENCE 700 1- Pohl Susanne Alfried Krupp Labor, Universitäts-Augenklinik, Sigmund-Freud-Strasse 25, D-5300, Bonn, Germany aut NATIONALLICENCE 773 0- Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/5(1990-09-01), 487-496 0721-832X 228:5<487 1990 228 417 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer