caa a22 4500 465778054 CHVBK 20180323111947.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF00927263 doi (NATIONALLICENCE)springer-10.1007/BF00927263 Panretinal photocoagulation aggravates experimental proliferative vitreoretinopathy [Elektronische Daten] [Peep Algvere, Kerstin Hallnäs, Eva Dafgård, Anders Höög] The effects of panretinal photocoagulation (PRP) on intravitreal proliferation were evaluated in an experimental model for proliferative vitreoretinopathy (PVR). Thirty-three pigmented rabbits underwent argon laser PRP in one eye. Cultured fibroblasts (2 x 105 or 4 x 105 cells) were implanted into the intact vitreous of both eyes of each animal either 3 days after PRP (when acute laser lesions were present) or 4 weeks after PRP (scarred laser lesions). PVR was assessed by indirect ophthalmoscopy for 4-8 weeks. Histological examination included staining with monoclonal antibodies against glial fibrillary acidic protein (GFAP). In both groups significantly more severe stages of PVR developed after PRP than in the controls. Total retinal detachments ensued in 13 photocoagulated eyes versus five controls. PRP induced invasion of macrophages, proliferation of retinal pigment epithelium and a conspicuous Müller cell response, enhancing intraocular inflammation, which stimulated intravitreal proliferation and aggravated PVR. Springer-Verlag, 1990 Algvere Peep Department of Ophthalmology, Sweden aut Hallnäs Kerstin Department of Ophthalmology, Sweden aut Dafgård Eva Department of Pathology, Karolinska Institute and Hospital, Box 60500, S-10401, Stockholm, Sweden aut Höög Anders Department of Pathology, Karolinska Institute and Hospital, Box 60500, S-10401, Stockholm, Sweden aut Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/5(1990-09-01), 461-466 0721-832X 228:5<461 1990 228 417 https://doi.org/10.1007/BF00927263 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00927263 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Algvere Peep Department of Ophthalmology, Sweden aut NATIONALLICENCE 700 1- Hallnäs Kerstin Department of Ophthalmology, Sweden aut NATIONALLICENCE 700 1- Dafgård Eva Department of Pathology, Karolinska Institute and Hospital, Box 60500, S-10401, Stockholm, Sweden aut NATIONALLICENCE 700 1- Höög Anders Department of Pathology, Karolinska Institute and Hospital, Box 60500, S-10401, Stockholm, Sweden aut NATIONALLICENCE 773 0- Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/5(1990-09-01), 461-466 0721-832X 228:5<461 1990 228 417 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer