caa a22 4500 465778062 CHVBK 20180323111947.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF00927251 doi (NATIONALLICENCE)springer-10.1007/BF00927251 Intraocular pressure in patients with Cushing's disease [Elektronische Daten] [Jost Jonas, Oliver Huschle, Gerhard Koniszewski, Michael Buchfelder, Rudolf Fahlbusch] Externally applied corticosteroids increase the intraocular pressure in one-third of the general population. We evaluated the intraocular pressure in 62 patients with endogenously elevated serum cortisol levels due to hypothalamic pituitary-dependent Cushing's disease. All patients underwent transphenoidal microsurgical sella exploration within 4 years after the onset of subjective symptoms. The intraocular pressure (preoperative mean, 14.9 ± 3.5 mm Hg) exceeded 21 mm Hg in four eyes before surgery and in one eye after surgery (postoperative mean, 14.3 ± 2.8 mm Hg). In patients attaining postoperative remission and whose pressure readings were taken at least 3 months after surgery, the postoperative intraocular pressure was significantly (P=0.04) lower than that measured preoperatively (14.2±2.7 vs 13.0 ±2.0 mm Hg). Biomorphometry of the optic disc topography and the retinal nerve-fiber layer in 19 patients revealed no glaucomatous changes. In contrast to topically applied corticosteroids, endogenously elevated serum cortisol levels in patients with hypothalamic pituitary-dependent Cushing's disease increased intraocular pressure only slightly, with no great risk of glaucomatous optic nerve damage. Springer-Verlag, 1990 Jonas Jost Universitäts-Augenklinik, Germany aut Huschle Oliver Universitäts-Augenklinik, Germany aut Koniszewski Gerhard Universitäts-Augenklinik, Germany aut Buchfelder Michael Neurochirurgische Universitätsklinik, Universität Erlangen-Nürnberg, Schwabachanlage 6, D-8520, Erlangen, Germany aut Fahlbusch Rudolf Neurochirurgische Universitätsklinik, Universität Erlangen-Nürnberg, Schwabachanlage 6, D-8520, Erlangen, Germany aut Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/5(1990-09-01), 407-409 0721-832X 228:5<407 1990 228 417 https://doi.org/10.1007/BF00927251 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00927251 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jonas Jost Universitäts-Augenklinik, Germany aut NATIONALLICENCE 700 1- Huschle Oliver Universitäts-Augenklinik, Germany aut NATIONALLICENCE 700 1- Koniszewski Gerhard Universitäts-Augenklinik, Germany aut NATIONALLICENCE 700 1- Buchfelder Michael Neurochirurgische Universitätsklinik, Universität Erlangen-Nürnberg, Schwabachanlage 6, D-8520, Erlangen, Germany aut NATIONALLICENCE 700 1- Fahlbusch Rudolf Neurochirurgische Universitätsklinik, Universität Erlangen-Nürnberg, Schwabachanlage 6, D-8520, Erlangen, Germany aut NATIONALLICENCE 773 0- Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/5(1990-09-01), 407-409 0721-832X 228:5<407 1990 228 417 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer