caa a22 4500 465778291 CHVBK 20180323111948.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF00935726 doi (NATIONALLICENCE)springer-10.1007/BF00935726 Histochemical studies on hyaluronic acid in the developing human retina [Elektronische Daten] [Noriyuki Azuma, Tetsuo Hida, Shinobu Akiya, Yasuo Uemura, Sinichi Kohsaka, Yasuzo Tsukada] Changes in the distribution of hyaluronic acid in the developing human retina were investigated histochemically with alcian blue staining and theStreptomyces hyaluronidase digestion method using 56 human embryos and fetuses ranging from 5 to 41 weeks of gestational age. Hyaluronic acid was first detected in the inner layer of the retina at 12 weeks. The site of accumulation extended towards the outer layer by 20 weeks. At the neonatal stage, longitudinal fibers, possibly the processes of Müller cells, were proved to contain hyaluronic acid. These findings suggest that Müller cells produce hyaluronic acid transiently from 12 weeks' gestation to the neonatal stage. Springer-Verlag, 1990 Azuma Noriyuki Department of Ophthalmology, Keio University School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo, Japan aut Hida Tetsuo Department of Ophthalmology, Keio University School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo, Japan aut Akiya Shinobu Department of Ophthalmology, Keio University School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo, Japan aut Uemura Yasuo Department of Ophthalmology, Keio University School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo, Japan aut Kohsaka Sinichi Department of Physiology, Keio University School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo, Japan aut Tsukada Yasuzo Department of Physiology, Keio University School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo, Japan aut Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/2(1990-03-01), 158-160 0721-832X 228:2<158 1990 228 417 https://doi.org/10.1007/BF00935726 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00935726 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Azuma Noriyuki Department of Ophthalmology, Keio University School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Hida Tetsuo Department of Ophthalmology, Keio University School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Akiya Shinobu Department of Ophthalmology, Keio University School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Uemura Yasuo Department of Ophthalmology, Keio University School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Kohsaka Sinichi Department of Physiology, Keio University School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Tsukada Yasuzo Department of Physiology, Keio University School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo, Japan aut NATIONALLICENCE 773 0- Graefe's Archive for Clinical and Experimental Ophthalmology Springer-Verlag 228/2(1990-03-01), 158-160 0721-832X 228:2<158 1990 228 417 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 46577704X BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer